Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 15/20 | 0.48 |
| ▸ | JAK2 | O60674 | 10/20 | 0.48 |
| ▸ | TYK2 | P29597 | 3/20 | 0.43 |
| ▸ | JAK3 | P52333 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22007006 | 0.92 | JAK1 (0.49) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL16718806 | 0.85 | ALDH1A1 (0.42) | JAK1JAK2TYK2JAK3ALDH1A1 | |
| SCHEMBL21757052 | 0.84 | JAK1 (0.43) | JAK1JAK2TYK2JAK3ALDH1A1 | |
| SCHEMBL22754610 | 0.81 | JAK1 (0.43) | JAK1JAK2TYK2JAK3ALDH1A1 | |
| SCHEMBL27271111 | 0.77 | EPHX2 (0.49) | JAK1JAK2TYK2JAK3ALDH1A1 | |
| SCHEMBL16835513 | 0.77 | ITGB3 (0.36) | ALDH1A1MEN1KMT2AITGB3ITGA2B | |
| SCHEMBL26286124 | 0.76 | JAK2 (0.41) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL21757048 | 0.75 | JAK1 (0.45) | JAK1JAK2TYK2JAK3ALDH1A1 | |
| SCHEMBL12463610 | 0.74 | JAK3 (0.49) | JAK1JAK2JAK3 | |
| SCHEMBL23029326 | 0.74 | L3MBTL1 (0.50) | ALDH1A1KDM4EMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3312164-A1 | SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE | Calitor Sciences, LLC (US) | 2018-04-25 | — | — | EP | disclosed |