Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HK1 | P19367 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | GALK1 | P51570 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4809130 | 0.82 | NOX1 (0.42) | ALOX5KMT2AHTR5A | |
| SCHEMBL29485911 | 0.82 | CMA1 (0.44) | ALOX5GAAKMT2AMAPTKDM4E | |
| SCHEMBL4811917 | 0.82 | CMA1 (0.44) | ALOX5GAAKMT2AMAPTKDM4E | |
| SCHEMBL4807696 | 0.82 | AHR (0.44) | ALOX5GAAKMT2ANPC1MAPT | |
| SCHEMBL4810558 | 0.82 | ALOX5 (0.41) | ALOX5GAAKMT2AMAPTKDM4E | |
| SCHEMBL11442210 | 0.82 | ALOX5 (0.48) | ALOX5GAANPSR1KMT2ANPC1 | |
| SCHEMBL4809989 | 0.80 | NR3C2 (0.47) | — | |
| SCHEMBL14279325 | 0.80 | AHR (0.41) | ALOX5GAAKMT2ANPC1MAPT | |
| SCHEMBL18173701 | 0.80 | MMP12 (0.61) | GAAKMT2ANPC1MAPTKDM4E | |
| SCHEMBL4806003 | 0.80 | NR3C2 (0.44) | ALOX5GAAKMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 127 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1475373-A1 | 5,11-Dihydrodibenzo[b,e][1,4]-oxazepine derivatives as calcium channel antagonists | Ajinomoto Co., Inc. (JP) | 2004-11-10 | — | — | EP | claimed |
| EP-1471060-A1 | 5,11-Dihydrodibenzo[b,e][1,4]-oxazepine derivatives as calcium channel antagonists | Ajinomoto Co., Inc. (JP) | 2004-10-27 | — | — | EP | claimed |
| US-6528504-B2 | Compounds such as (R)-5,11-dihydro-5-(1-(4-methoxyphenethyl)-piperidine-2-ylmethyl) -dibenzo(b,e)(1,4) oxazepine are useful for treating or preventing abnormal motor functions of gastrointestinal tracts, e.g., irritable bowel syndrome. | AJINOMOTO CO., INC. (JP) | 2003-03-04 | — | — | US | claimed |
| EP-1020466-B1 | 5,11-DIHYDRODIBENZ[b,e][1,4]OXAZEPINE DERIVATIVES AND MEDICINAL COMPOSITION CONTAINING THE SAME | AJINOMOTO KK (JP) | 2003-02-19 | — | — | EP | claimed |
| US-20020133004-A1 | Process for producing new oxazepine derivatives | AJINOMOTO CO. INC (JP) | 2002-09-19 | — | — | US | claimed |
| US-6436922-B1 | TREATING IRRITABLE BOWEL SYNDROME | AJINOMOTO CO., INC. (JP) | 2002-08-20 | — | — | US | claimed |
| US-20020099047-A1 | Oxazepine derivatives and medicine containing the same | AJINOMOTO CO., INC. (JP) | 2002-07-25 | — | — | US | claimed |
| EP-1219611-A1 | NOVEL PROCESSES FOR PREPARING OXAZEPINE DERIVATIVES | Ajinomoto Co., Inc. (JP) | 2002-07-03 | — | — | EP | claimed |
| EP-1142884-A1 | OXAZEPINE DERIVATIVES AND DRUGS CONTAINING THE SAME | Ajinomoto Co., Inc. (JP) | 2001-10-10 | — | — | EP | claimed |
| EP-0889043-B1 | 5,11-DIHYDRODIBENZ b,e] 1,4]OXAZEPINE DERIVATIVES AND DRUG COMPOSITIONS CONTAING THE DERIVATIVES | AJINOMOTO KK (JP) | 2001-08-29 | — | — | EP | claimed |
| US-6127361-A | FOR TREATMENT OR PREVENTION OF GASTROINTESTINAL MOVING FUNCTION DISORDERS, IRRITABLE BOWEL SYNDROME | AJINOMO CO., INC. (JP) | 2000-10-03 | — | — | US | claimed |
| EP-1020466-A1 | 5,11-DIHYDRODIBENZ[b,e][1,4]OXAZEPINE DERIVATIVES AND MEDICINAL COMPOSITION CONTAINING THE SAME | Ajinomoto Co., Inc. (JP) | 2000-07-19 | — | — | EP | claimed |
| EP-0889043-A1 | 5,11-DIHYDRODIBENZ b,e] 1,4]OXAZEPINE DERIVATIVES AND DRUG COMPOSITIONS CONTAING THE DERIVATIVES | Ajinomoto Co., Inc. (JP) | 1999-01-07 | — | — | EP | claimed |
| US-12152216-B2 | Benzazepine compounds as antioxidants for lubricant compositions | The Lubrizol Corp tion (US) | 2024-11-26 | — | — | US | disclosed |
| CN-115536585-B | Iminostilbene derivative and preparation method thereof | 中国医学科学院药用植物研究所 | 2024-04-30 | — | — | CN | disclosed |
| US-20240052256-A1 | BENZAZEPINE COMPOUNDS AS ANTIOXIDANTS FOR LUBRICANT COMPOSITIONS | THE LUBRIZOL CORPORATION | 2024-02-15 | — | — | US | disclosed |
| EP-0613472-A1 | 10-ACYL-DIBENZ(B,F) (1,4)-OXAZEPINES AND THEIR THIAZEPINES ANALO GUES USEFUL AS PROSTAGLANDIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1994-09-07 | — | — | EP | disclosed |
| EP-0607864-A2 | Tricyclic condensed heterocyclic compounds for the treatment of senile dementic | Takeda Chemical Industries, Ltd. (JP) | 1994-07-27 | — | — | EP | disclosed |
| US-4229350-A | LOCAL ANESTHETICS, TREATMENT OF PARKINSON SYNDROME | EGYT GYOGYSZERVEGYESZETI GYAR (HU) | 1980-10-21 | — | — | US | disclosed |
| US-4208410-A | LOCAL ANESTHETICS, ANTIPARKINSON AGENTS | EGYT GYOGYSZERVEGYESZETI GYAR (HU) | 1980-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020099047-A1 | Oxazepine derivatives and medicine containing the same | CACNG5, GRIK5, KCNB1 | ALOX5 138/4885GAA 2017/4885NPSR1 910/4885 |
| US-20020133004-A1 | Process for producing new oxazepine derivatives | KMO, CYP4B1, GRIN2B | ALOX5 235/4885GAA 2540/4885NPSR1 1471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.