SCHEMBL2008949

SCHEMBL2008949

O=C(c1ncc(-c2cccnc2)o1)c1c(C(F)(F)F)n(Cc2ccc(Cl)cc2)c2ccc(O)cc12

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGES2 Q9H7Z7 2/20 0.41
ALOX5AP P20292 2/20 0.37
ALOX5 P09917 1/20 0.37
MCHR1 Q99705 1/20 0.36
MAPT P10636 3/20 0.35
KDM4E B2RXH2 2/20 0.35
ALDH1A1 P00352 2/20 0.35
HPGD P15428 1/20 0.35
ALOX15 P16050 1/20 0.35
ALOX12 P18054 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
HSD17B10 Q99714 1/20 0.35
FAAH O00519 1/20 0.35
GRIN1 Q05586 2/20 0.34
GRIN2B Q13224 2/20 0.34
HDAC6 Q9UBN7 3/20 0.34
HDAC1 Q13547 2/20 0.34
SRPK1 Q96SB4 1/20 0.34
PKM P14618 2/20 0.34
GAA P10253 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2002134 0.94 PTGES2 (0.42) PTGES2ALOX5APALOX5MCHR1MAPT
SCHEMBL1999580 0.92 MAPT (0.39) PTGES2ALOX5APALOX5MAPTKDM4E
SCHEMBL2005859 0.91 PTGES2 (0.44) PTGES2ALOX5APALOX5MCHR1MAPT
SCHEMBL2002457 0.91 ALOX5 (0.36) PTGES2ALOX5APALOX5MCHR1MAPT
SCHEMBL2008663 0.91 L3MBTL1 (0.36) PTGES2MCHR1MAPTKDM4EALDH1A1
SCHEMBL2006671 0.90 PTGES2 (0.40) PTGES2MCHR1MAPTKDM4EALDH1A1
SCHEMBL2004090 0.89 PTGES2 (0.40) PTGES2ALOX5APALOX5MAPTKDM4E
SCHEMBL2004581 0.89 ALOX5AP (0.41) PTGES2ALOX5APALOX5MAPTALDH1A1
SCHEMBL2002959 0.89 ALOX5AP (0.42) PTGES2ALOX5APALOX5MAPTKDM4E
SCHEMBL2003185 0.87 PTGES2 (0.41) PTGES2ALOX5APALOX5MCHR1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7960544-B2 Useful indole compounds IRONWOOD PHARMACEUTICALS, INC. (US) 2011-06-14 US disclosed