Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | AGXT | P21549 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 6/20 | 0.41 |
| ▸ | ACLY | P53396 | 2/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 2/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2006613 | 0.87 | KIF11 (0.50) | KIF11 | |
| SCHEMBL2013468 | 0.81 | KIF11 (0.46) | KIF11PTGDR2 | |
| SCHEMBL2009300 | 0.81 | KIF11 (0.47) | DHODHKIF11LTB4R | |
| SCHEMBL2006223 | 0.77 | POLB (0.43) | DHODHMCL1 | |
| SCHEMBL2005594 | 0.76 | MMP2 (0.51) | LTB4R | |
| SCHEMBL2010419 | 0.76 | FFAR4 (0.41) | LTB4R | |
| SCHEMBL2003518 | 0.74 | PGR (0.44) | — | |
| SCHEMBL4399152 | 0.73 | KIF11 (0.54) | PTGES2DHODHAGXTKIF11ACLY | |
| SCHEMBL28155932 | 0.73 | AGXT (0.57) | DHODHAGXTKIF11MGLL | |
| SCHEMBL2006136 | 0.73 | PTGS2 (0.44) | KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7964643-B2 | Biphenyl-4-sulfonic acid-(4-hydroxybutyl)-amide and derivatives; inhibits osteoclast survival, formation, and/or activity and/or inhibits bone resorption; osteoporosis, rheumatoid arthritis, cancer associated bone disease, Paget's disease, antiinflammatory, -carcinogenic agents; immunostimulants | THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN (GB) | 2011-06-21 | — | — | US | disclosed |