Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 14/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.46 |
| ▸ | PRKDC | P78527 | 7/20 | 0.46 |
| ▸ | SRC | P12931 | 8/20 | 0.43 |
| ▸ | ABL1 | P00519 | 7/20 | 0.43 |
| ▸ | HCK | P08631 | 7/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 6/20 | 0.43 |
| ▸ | KDR | P35968 | 6/20 | 0.43 |
| ▸ | MTOR | P42345 | 6/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 6/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.43 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19414292 | 0.78 | SRC (0.42) | PIK3CGPIK3CBPRKDCSRCABL1 | |
| SCHEMBL13717800 | 0.78 | CSNK1E (0.45) | PIK3CDPIK3CGPIK3CAPIK3CBPRKDC | |
| SCHEMBL130467 | 0.74 | PIK3CD (0.61) | PIK3CDPIK3CGPIK3CAPIK3CBPRKDC | |
| SCHEMBL129575 | 0.70 | SRC (0.53) | PIK3CDPIK3CGPIK3CAPIK3CBPRKDC | |
| SCHEMBL13717774 | 0.69 | PIK3CD (0.41) | PIK3CDPIK3CGPIK3CAPIK3CBPRKDC | |
| SCHEMBL27943326 | 0.68 | PIK3CD (0.50) | PIK3CDPIK3CGPIK3CAPIK3CBPRKDC | |
| SCHEMBL26973954 | 0.68 | KDR (0.50) | PIK3CDPIK3CGPIK3CAPIK3CBPRKDC | |
| SCHEMBL217790 | 0.67 | ABL1 (0.49) | PIK3CDPIK3CGPIK3CAPIK3CBPRKDC | |
| SCHEMBL13717931 | 0.67 | SRC (0.48) | PIK3CDPIK3CGPIK3CAPIK3CBPRKDC | |
| SCHEMBL22854507 | 0.67 | SRC (0.35) | PIK3CDPIK3CGPIK3CAPIK3CBPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10322130-B2 | Substituted chromenones as modulators of protein kinases | RHIZEN PHARMACEUTICALS SA (CH) | 2019-06-18 | — | — | US | disclosed |
| US-20190105324-A9 | SUBSTITUTED CHROMENONES AS MODULATORS OF PROTEIN KINASES | RHIZEN PHARMACEUTICALS AG (CH) | 2019-04-11 | — | — | US | disclosed |
| US-20180110783-A1 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | RHIZEN PHARMACEUTICALS SA (CH) | 2018-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190105324-A9 | SUBSTITUTED CHROMENONES AS MODULATORS OF PROTEIN KINASES | PRKCA, PRKCH, PRKAR2B | PIK3CD 89/4885PIK3CG 128/4885PIK3CA 106/4885 |
| US-20180110783-A1 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | PRKCA, PRKCH, PRKCB | PIK3CD 47/4885PIK3CG 77/4885PIK3CA 88/4885 |
| US-10322130-B2 | Substituted chromenones as modulators of protein kinases | MAP3K1, CSNK1A1, MAP3K2 | PIK3CD 148/4885PIK3CG 194/4885PIK3CA 153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.