Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 15/20 | 0.49 |
| ▸ | SRC | P12931 | 15/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 14/20 | 0.49 |
| ▸ | HCK | P08631 | 14/20 | 0.49 |
| ▸ | EGFR | P00533 | 13/20 | 0.49 |
| ▸ | KDR | P35968 | 13/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 13/20 | 0.49 |
| ▸ | MTOR | P42345 | 13/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 13/20 | 0.49 |
| ▸ | EPHB4 | P54760 | 13/20 | 0.49 |
| ▸ | PRKDC | P78527 | 13/20 | 0.49 |
| ▸ | PI4KB | Q9UBF8 | 12/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11306 | 0.88 | SRC (0.47) | ABL1SRCPIK3CDHCKEGFR | |
| SCHEMBL16665685 | 0.86 | PIK3CD (0.67) | ABL1SRCPIK3CDHCKEGFR | |
| SCHEMBL13826606 | 0.85 | PIK3CD (0.47) | ABL1SRCPIK3CDHCKEGFR | |
| SCHEMBL13717800 | 0.85 | CSNK1E (0.45) | ABL1SRCPIK3CDHCKEGFR | |
| SCHEMBL13717774 | 0.83 | PIK3CD (0.41) | ABL1SRCPIK3CDHCKEGFR | |
| SCHEMBL3235988 | 0.82 | EGFR (0.45) | EGFR | |
| SCHEMBL22692856 | 0.81 | ERBB2 (0.50) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL10811 | 0.81 | SRC (0.57) | ABL1SRCPIK3CDHCKEGFR | |
| SCHEMBL19414293 | 0.80 | ALDH1A1 (0.50) | ABL1SRCPIK3CDHCKEGFR | |
| SCHEMBL20093454 | 0.80 | SRC (0.61) | ABL1SRCPIK3CDHCKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160318890-A1 | NOVEL KINASE MODULATORS | RHIZEN PHARMACEUTICALS AG (CH) | 2016-11-03 | — | — | US | disclosed |
| US-20150320752-A1 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | RHIZEN PHARMACEUTICALS AG (CH) | 2015-11-12 | — | — | US | disclosed |
| US-9018375-B2 | Substituted chromenes as kinase modulators | RHIZEN PHARMACEUTICALS SA (CH) | 2015-04-28 | — | — | US | disclosed |
| US-20140080827-A1 | NOVEL KINASE MODULATORS | RHIZEN PHARMACEUTICALS SA (CH) | 2014-03-20 | — | — | US | disclosed |
| US-8642607-B2 | 4H-chromen-4-one compounds as modulators of protein kinases | RHIZEN PHARMACEUTICALS SA (CH) | 2014-02-04 | — | — | US | disclosed |
| US-20120059001-A1 | NOVEL KINASE MODULATORS | INCOZEN THERAPEUTICS PVT. LTD. (IN) | 2012-03-08 | — | — | US | disclosed |
| US-20110118257-A1 | NOVEL KINASE MODULATORS | RHIZEN PHARMACEUTICALS SA (CH) | 2011-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150320752-A1 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | PRKCA, PRKCH, PRKCB | ABL1 334/4885SRC 285/4885PIK3CD 47/4885 |
| US-20140080827-A1 | NOVEL KINASE MODULATORS | PRKCA, PRKCH, PRKCB | ABL1 465/4885SRC 314/4885PIK3CD 70/4885 |
| US-20110118257-A1 | NOVEL KINASE MODULATORS | PRKCA, PRKCH, PRKCB | ABL1 465/4885SRC 314/4885PIK3CD 70/4885 |
| US-20160318890-A1 | NOVEL KINASE MODULATORS | PRKCA, PRKCH, PRKCB | ABL1 465/4885SRC 314/4885PIK3CD 70/4885 |
| US-20120059001-A1 | NOVEL KINASE MODULATORS | PRKCA, PRKCH, PRKCB | ABL1 465/4885SRC 314/4885PIK3CD 70/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.