Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | DDX3X | O00571 | 1/20 | 0.57 |
| ▸ | ULK1 | O75385 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.49 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4230443 | 0.94 | DDX3X (0.65) | GAASMN1; SMN2USP2LMNAHPGD | |
| SCHEMBL12825257 | 0.87 | NPSR1 (0.65) | GAASMN1; SMN2USP2LMNAHPGD | |
| SCHEMBL1242082 | 0.87 | NPSR1 (0.69) | GAASMN1; SMN2USP2LMNAHPGD | |
| SCHEMBL20332958 | 0.86 | ALDH1A1 (0.68) | SMN1; SMN2USP2LMNAHPGDDDX3X | |
| SCHEMBL4218895 | 0.86 | ALDH1A1 (0.68) | SMN1; SMN2USP2LMNAHPGDDDX3X | |
| SCHEMBL13716767 | 0.84 | GAA (0.56) | GAASMN1; SMN2USP2LMNAHPGD | |
| SCHEMBL3211109 | 0.83 | GAA (0.72) | GAASMN1; SMN2USP2LMNAHPGD | |
| SCHEMBL3211102 | 0.83 | GAA (0.72) | GAASMN1; SMN2USP2LMNAHPGD | |
| SCHEMBL31609680 | 0.81 | MTNR1A (0.72) | GAASMN1; SMN2LMNAALDH1A1NPSR1 | |
| SCHEMBL12825253 | 0.81 | ALDH1A1 (0.54) | GAASMN1; SMN2USP2LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10695346-B2 | 4,6-pyrimidinylene derivatives and uses thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-06-30 | — | — | US | disclosed |
| US-20180110778-A1 | 4,6-PYRIMIDINYLENE DERIVATIVES AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10695346-B2 | 4,6-pyrimidinylene derivatives and uses thereof | CDK3, CDK1, CDK14 | GAA 4222/4885SMN1; SMN2 1640/4885USP2 1925/4885 |
| US-20180110778-A1 | 4,6-PYRIMIDINYLENE DERIVATIVES AND USES THEREOF | CDKL4, CDKL5, PIP5K1A | GAA 3551/4885SMN1; SMN2 2185/4885USP2 2009/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.