Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A1 | O15245 | 1/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12162985 | 1.00 | SLC22A1 (0.56) | SLC22A1OPRM1L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL12163005 | 1.00 | SLC22A1 (0.56) | SLC22A1OPRM1L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL19072752 | 0.93 | SLC22A1 (0.48) | SLC22A1OPRM1L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2009363 | 0.80 | L3MBTL1 (0.49) | L3MBTL1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL12015811 | 0.77 | L3MBTL1 (0.64) | L3MBTL1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6411376 | 0.74 | SLC22A1 (0.70) | SLC22A1OPRM1CYP3A4 | |
| Tapentadol SCHEMBL415565 | 0.73 | SLC22A1 (0.82) | SLC22A1OPRM1MEN1KMT2ARAB9A | |
| Tapentadol SCHEMBL17104708 | 0.73 | OPRM1 (0.94) | SLC22A1OPRM1ALDH1A1CYP1A2CYP2C9 | |
| Tapentadol SCHEMBL147058 | 0.73 | OPRM1 (1.00) | SLC22A1OPRM1ALDH1A1CYP1A2CYP2C9 | |
| Tapentadol SCHEMBL16267909 | 0.73 | OPRM1 (1.00) | SLC22A1OPRM1ALDH1A1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507203-B1 | NEW PROCESS FOR THE PREPARATION OF TAPENTADOL AND INTERMEDIATES THEREOF | EUTICALS SPA (IT) | 2017-07-05 | — | — | EP | disclosed |
| US-8729308-B2 | Process for the preparation of tapentadol and intermediates thereof | EUTICALS S.P.A. (IT) | 2014-05-20 | — | — | US | disclosed |
| EP-2507203-A1 | NEW PROCESS FOR THE PREPARATION OF TAPENTADOL AND INTERMEDIATES THEREOF | Euticals S.P.A. (IT) | 2012-10-10 | — | — | EP | disclosed |
| US-20120232306-A1 | PROCESS FOR THE PREPARATION OF TAPENTADOL AND INTERMEDIATES THEREOF | EUTICALS S.P.A. (IT) | 2012-09-13 | — | — | US | disclosed |
| WO-2011067714-A1 | NEW PROCESS FOR THE PREPARATION OF TAPENTADOL AND INTERMEDIATES THEREOF | ARCHIMICA SRL (IT) | 2011-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120232306-A1 | PROCESS FOR THE PREPARATION OF TAPENTADOL AND INTERMEDIATES THEREOF | OPRK1, OPRD1, OPRL1 | SLC22A1 3207/4885OPRM1 4/4885L3MBTL1 3801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.