Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | GABRP | O00591 | 1/20 | 0.45 |
| ▸ | GABRD | O14764 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.45 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.45 |
| ▸ | GABRE | P78334 | 1/20 | 0.45 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.45 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.45 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.45 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.45 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15318252 | 0.83 | BAZ2B (0.50) | BAZ2BBAZ2AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL30693785 | 0.81 | GABRP (0.41) | MMP13ALOX15MAPTGABRPGABRD | |
| SCHEMBL4420297 | 0.81 | GABRP (0.45) | MMP13ALOX15MAPTGABRPGABRD | |
| SCHEMBL7298381 | 0.76 | ROCK2 (0.50) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL2148753 | 0.76 | GABRP (0.51) | MMP13ALOX15MAPTGABRPGABRD | |
| SCHEMBL15318227 | 0.76 | HSD17B10 (0.45) | MAPTALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL20094767 | 0.76 | DAO (0.49) | ALOX15MAPTALDH1A1HPGDLMNA | |
| SCHEMBL4674699 | 0.76 | BAZ2B (0.53) | MMP13MAPTGABRPGABRDGABRA1 | |
| SCHEMBL14791060 | 0.75 | GABRA1 (0.50) | MMP13ALOX15MAPTGABRPGABRD | |
| SCHEMBL162674 | 0.75 | GABRP (0.50) | MMP13ALOX15MAPTGABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018075842-A1 | CONDENSED BENZODIAZEPINE DERIVATIVES AND CONJUGATES MADE THEREFROM | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-04-26 | — | — | WO | disclosed |