Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2002838 | 0.94 | LMNA (0.45) | LMNAMAPK1KMT2ATSHRGSK3A | |
| SCHEMBL2002347 | 0.93 | PPARG (0.37) | LMNAMAPK1TSHRMAPTSMN1; SMN2 | |
| SCHEMBL2002445 | 0.91 | LMNA (0.43) | LMNAMAPK1KMT2ATSHRGSK3A | |
| SCHEMBL2005825 | 0.91 | RET (0.38) | LMNAMAPK1TSHRPKMMAPT | |
| SCHEMBL2007059 | 0.91 | MAPK1 (0.41) | LMNAMAPK1KMT2ATSHRGSK3A | |
| SCHEMBL2006683 | 0.90 | MAPK1 (0.47) | LMNAMAPK1KMT2ATSHRPKM | |
| SCHEMBL2003530 | 0.90 | MAPK1 (0.45) | LMNAMAPK1KMT2ATSHRGSK3A | |
| SCHEMBL2004245 | 0.90 | LMNA (0.45) | LMNAMAPK1KMT2ATSHRGSK3A | |
| SCHEMBL1999740 | 0.90 | LMNA (0.45) | LMNAMAPK1KMT2ATSHRGSK3A | |
| SCHEMBL2004842 | 0.89 | FAAH (0.33) | LMNAMAPK1MAPTSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |