Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2002838 | 0.95 | LMNA (0.45) | LMNAMAPK1KMT2ATSHRGSK3A | |
| SCHEMBL2005140 | 0.93 | L3MBTL1 (0.41) | LMNAMAPK1KMT2ATSHRL3MBTL1 | |
| SCHEMBL2009477 | 0.91 | LMNA (0.42) | LMNAMAPK1KMT2ATSHRGSK3A | |
| SCHEMBL2004562 | 0.91 | RET (0.37) | LMNAMAPK1L3MBTL1PKMALDH1A1 | |
| SCHEMBL2003530 | 0.90 | MAPK1 (0.45) | LMNAMAPK1KMT2ATSHRGSK3A | |
| SCHEMBL2000262 | 0.90 | MAPK1 (0.48) | LMNAMAPK1KMT2ATSHRPKM | |
| SCHEMBL2007059 | 0.90 | MAPK1 (0.41) | LMNAMAPK1KMT2ATSHRGSK3A | |
| SCHEMBL2000320 | 0.89 | LMNA (0.46) | LMNAMAPK1KMT2ATSHRGSK3A | |
| SCHEMBL2002081 | 0.89 | L3MBTL1 (0.35) | LMNAMAPK1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL2008151 | 0.88 | LMNA (0.39) | LMNAMAPK1KMT2ATSHRGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| EP-2049520-A2 | INDOLE COMPOUNDS | Ironwood Pharmaceuticals, Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008019357-A2 | INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |