Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | PTPRB | P23467 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18112907 | 0.84 | CYP2C9 (0.55) | HRH3CYP2C9CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL25587767 | 0.82 | CYP1A2 (0.40) | CYP2C9CYP1A2CYP2D6CYP2C19NPSR1 | |
| SCHEMBL20585007 | 0.82 | CYP1A2 (0.40) | CYP2C9CYP1A2CYP2D6CYP2C19NPSR1 | |
| SCHEMBL23961649 | 0.82 | CYP1A2 (0.40) | CYP2C9CYP1A2CYP2D6CYP2C19NPSR1 | |
| SCHEMBL23972532 | 0.81 | HRH3 (0.50) | HRH3CYP2C9ALDH1A1TSHRTAAR1 | |
| SCHEMBL23961650 | 0.80 | NPSR1 (0.52) | HRH3CYP2C9CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL18421556 | 0.79 | HPGD (0.45) | CYP2C9CYP1A2CYP2D6CYP2C19NPSR1 | |
| SCHEMBL377446 | 0.79 | CYP1A2 (0.41) | CYP2C9CYP1A2CYP2D6CYP2C19NPSR1 | |
| SCHEMBL8251603 | 0.78 | HRH3 (0.46) | HRH3CYP2C9ALDH1A1TSHRTAAR1 | |
| SCHEMBL29473761 | 0.78 | HRH3 (0.46) | HRH3ALDH1A1TSHRTAAR1HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10793549-B2 | Sulfuryl-substituted benzoheterocyclic derivative, preparation method and medical use thereof | SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) | 2020-10-06 | — | — | US | disclosed |
| US-10654852-B2 | Antibiotics and methods of using same | THE BROAD INSTITUTE, INC. (US) | 2020-05-19 | — | — | US | disclosed |
| US-20190300506-A1 | SULFONYL-SUBSTITUTED BENZOHETEROCYCLIC DERIVATIVE, PREPARATION METHOD AND MEDICAL USE THEREOF | YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD. (CN) | 2019-10-03 | — | — | US | disclosed |
| US-20190240203-A1 | NOVEL ANTIBIOTICS AND METHODS OF USING SAME | THE BROAD INSTITUTE, INC. (US) | 2019-08-08 | — | — | US | disclosed |
| WO-2018075871-A1 | NOVEL ANTIBIOTICS AND METHODS OF USING SAME | THE BROAD INSTITUTE, INC. (US) | 2018-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190300506-A1 | SULFONYL-SUBSTITUTED BENZOHETEROCYCLIC DERIVATIVE, PREPARATION METHOD AND MEDICAL USE THEREOF | STS, SLC5A2, SULT2A1 | HRH3 2044/4885CYP2C9 17/4885CYP1A2 64/4885 |
| US-20190240203-A1 | NOVEL ANTIBIOTICS AND METHODS OF USING SAME | NRDC, TLR6, PEPD | HRH3 2176/4885CYP2C9 1784/4885CYP1A2 2148/4885 |
| US-10654852-B2 | Antibiotics and methods of using same | NRDC, PEPD, TREH | HRH3 3013/4885CYP2C9 698/4885CYP1A2 955/4885 |
| US-10793549-B2 | Sulfuryl-substituted benzoheterocyclic derivative, preparation method and medical use thereof | STS, SULT2A1, CYP2A13 | HRH3 1027/4885CYP2C9 14/4885CYP1A2 57/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.