Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 4/20 | 0.37 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7815804 | 0.81 | NPC1 (0.45) | NOTUM | |
| SCHEMBL7803709 | 0.81 | NPC1 (0.45) | NOTUM | |
| SCHEMBL20095693 | 0.75 | CYP11B1 (0.41) | KIF11CYP11B1CYP11B2 | |
| SCHEMBL20095695 | 0.75 | CYP11B1 (0.41) | KIF11CYP11B1CYP11B2 | |
| SCHEMBL21311678 | 0.74 | HPGD (0.40) | NOTUMGAA | |
| SCHEMBL20096223 | 0.73 | CYP11B1 (0.37) | P2RY14GAATDP1CYP11B1CYP11B2 | |
| SCHEMBL20096238 | 0.73 | HTR1A (0.42) | KIF11 | |
| SCHEMBL20096263 | 0.73 | HTR1A (0.42) | KIF11 | |
| SCHEMBL20096135 | 0.71 | KIF11 (0.32) | KIF11P2RY14CYP11B1CYP11B2 | |
| SCHEMBL9631576 | 0.71 | TRPV1 (0.42) | NOTUMS1PR1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |