Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.42 |
| ▸ | HTR7 | P34969 | 3/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | KIF11 | P52732 | 7/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20096238 | 1.00 | HTR1A (0.42) | HTR1AHTR7MCHR1HTR2AHTR2C | |
| SCHEMBL20096104 | 0.82 | HTR1A (0.55) | HTR1AHTR7HTR2AHTR2CHTR2B | |
| SCHEMBL20095695 | 0.78 | CYP11B1 (0.41) | KIF11TRPV1 | |
| SCHEMBL20095693 | 0.78 | CYP11B1 (0.41) | KIF11TRPV1 | |
| SCHEMBL21311610 | 0.71 | NISCH (0.40) | HTR1AHTR7 | |
| SCHEMBL21311611 | 0.71 | NISCH (0.40) | HTR1AHTR7 | |
| SCHEMBL20095850 | 0.71 | HTR1A (0.36) | HTR1AHTR7 | |
| SCHEMBL20096135 | 0.71 | KIF11 (0.32) | KIF11TRPV1 | |
| SCHEMBL20095952 | 0.70 | HTR2A (0.39) | HTR1AHTR7HTR2AHTR2CHTR2B | |
| SCHEMBL20095951 | 0.70 | HTR2A (0.39) | HTR1AHTR7HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |