Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 5/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 4/20 | 0.39 |
| ▸ | KDM1A | O60341 | 3/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20095695 | 1.00 | CYP11B1 (0.41) | CYP11B1CYP11B2KIF11TRPV1MAOB | |
| SCHEMBL20096263 | 0.78 | HTR1A (0.42) | KIF11TRPV1 | |
| SCHEMBL20096238 | 0.78 | HTR1A (0.42) | KIF11TRPV1 | |
| SCHEMBL30452552 | 0.77 | DRD2 (0.45) | — | |
| SCHEMBL29664619 | 0.77 | DRD2 (0.45) | — | |
| SCHEMBL29664651 | 0.77 | DRD2 (0.45) | — | |
| SCHEMBL20095705 | 0.75 | NOTUM (0.46) | CYP11B1CYP11B2KIF11 | |
| SCHEMBL20096135 | 0.73 | KIF11 (0.32) | CYP11B1CYP11B2KIF11TRPV1PTGS1 | |
| SCHEMBL18820302 | 0.69 | MAOB (0.39) | CYP11B1CYP11B2KIF11MAOBKDM1A | |
| SCHEMBL20095853 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |