Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | PRKACG | P22612 | 1/20 | 0.34 |
| ▸ | PRKACB | P22694 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17194382 | 0.86 | HRH3 (0.41) | HRH3ALDH1A1TSHRTAAR1CYP19A1 | |
| SCHEMBL15716128 | 0.81 | MAOB (0.39) | ALDH1A1TSHRCYP19A1MAOBCYP1A2 | |
| SCHEMBL19682405 | 0.79 | CYP2A6 (0.47) | ALDH1A1TSHRMAOBCYP1A2CYP2D6 | |
| SCHEMBL18006944 | 0.79 | PYCR1 (0.46) | HRH3ALDH1A1TAAR1CYP19A1HTR7 | |
| SCHEMBL30762181 | 0.77 | CYP1A2 (0.41) | HRH3ALDH1A1TSHRCYP19A1CYP1A2 | |
| SCHEMBL29278121 | 0.77 | CYP1A2 (0.41) | HRH3ALDH1A1TSHRCYP19A1CYP1A2 | |
| SCHEMBL20095630 | 0.76 | LOXL2 (0.50) | TAAR1MAOBHTR7MAOANOS1 | |
| SCHEMBL24197155 | 0.76 | SRC (0.39) | HRH3ALDH1A1TSHRTAAR1LMNA | |
| SCHEMBL20096075 | 0.76 | LOXL2 (0.47) | HRH3MAOBCA2MAOAGAA | |
| SCHEMBL17157484 | 0.76 | PTPRC (0.38) | MAOBCYP1A2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10654852-B2 | Antibiotics and methods of using same | THE BROAD INSTITUTE, INC. (US) | 2020-05-19 | — | — | US | disclosed |
| US-20190240203-A1 | NOVEL ANTIBIOTICS AND METHODS OF USING SAME | THE BROAD INSTITUTE, INC. (US) | 2019-08-08 | — | — | US | disclosed |
| WO-2018075871-A1 | NOVEL ANTIBIOTICS AND METHODS OF USING SAME | THE BROAD INSTITUTE, INC. (US) | 2018-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190240203-A1 | NOVEL ANTIBIOTICS AND METHODS OF USING SAME | NRDC, TLR6, PEPD | HRH3 2176/4885ALDH1A1 2254/4885TSHR 4145/4885 |
| US-10654852-B2 | Antibiotics and methods of using same | NRDC, PEPD, TREH | HRH3 3013/4885ALDH1A1 1694/4885TSHR 4317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.