SCHEMBL20100319

SCHEMBL20100319

C=C(C)C(=O)NC(=O)C(C)(C)CC

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
RIPK1 Q13546 4/20 0.41
LMNA P02545 1/20 0.36
POLB P06746 1/20 0.36
TGFBR1 P36897 1/20 0.33
ALDH1A1 P00352 3/20 0.32
KDM4E B2RXH2 1/20 0.32
L3MBTL1 Q9Y468 2/20 0.32
GAA P10253 1/20 0.32
THRB P10828 1/20 0.32
HTT P42858 1/20 0.32
CCR2 P41597 1/20 0.31
RXFP1 Q9HBX9 1/20 0.31
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
TDP1 Q9NUW8 1/20 0.30
DRD2 P14416 1/20 0.30
DRD4 P21917 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20100476 0.83 RIPK1 (0.43) RIPK1LMNAPOLBALDH1A1L3MBTL1
SCHEMBL14428590 0.79 RIPK1 (0.45) RIPK1LMNAPOLBALDH1A1L3MBTL1
SCHEMBL20100303 0.79 RIPK1 (0.38) RIPK1LMNAPOLBALDH1A1L3MBTL1
SCHEMBL10033554 0.79 RIPK1 (0.41) RIPK1LMNAPOLBTGFBR1DRD2
SCHEMBL15045387 0.78 L3MBTL1 (0.39) LMNATGFBR1ALDH1A1KDM4EL3MBTL1
SCHEMBL12017039 0.78 RIPK1 (0.41) RIPK1LMNAPOLBALDH1A1KDM4E
SCHEMBL16256514 0.77 RXFP1 (0.53) RIPK1LMNAPOLBALDH1A1L3MBTL1
SCHEMBL12716899 0.73 RIPK1 (0.37) RIPK1THRBMEN1KMT2ADRD2
SCHEMBL14997672 0.73 RIPK1 (0.41) RIPK1LMNAPOLBALDH1A1L3MBTL1
SCHEMBL14838796 0.73 RIPK1 (0.46) RIPK1LMNAPOLBALDH1A1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10042259-B2 Topcoat compositions and pattern-forming methods ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2018-08-07 US disclosed
US-10042259-B2 Topcoat compositions and pattern-forming methods ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2018-08-07 US disclosed
US-20180118970-A1 TOPCOAT COMPOSITIONS AND PATTERN-FORMING METHODS ROHM AND HAAS ELECTRONIC MATERIALS LLC 2018-05-03 US disclosed
US-20180118970-A1 TOPCOAT COMPOSITIONS AND PATTERN-FORMING METHODS ROHM AND HAAS ELECTRONIC MATERIALS LLC 2018-05-03 US disclosed