Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.61 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.51 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | GCGR | P47871 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16595789 | 0.86 | NPC1 (0.58) | NPC1RXFP1MAPTKMT2AMEN1 | |
| SCHEMBL12002570 | 0.86 | TP53 (0.60) | NPC1RXFP1MAPTKMT2AMEN1 | |
| SCHEMBL12783515 | 0.86 | NPC1 (0.50) | NPC1RXFP1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL1222552 | 0.85 | NPC1 (0.62) | NPC1MAPTKMT2AMEN1RAB9A | |
| SCHEMBL811649 | 0.85 | CA12 (0.56) | NPC1MAPTKMT2AMEN1RAB9A | |
| SCHEMBL29800427 | 0.85 | CA12 (0.56) | NPC1MAPTKMT2AMEN1RAB9A | |
| SCHEMBL2009526 | 0.84 | HPGDS (0.64) | NPC1MAPTKMT2AMEN1RAB9A | |
| SCHEMBL1966802 | 0.84 | NPC1 (0.67) | NPC1RXFP1MAPTKMT2AMEN1 | |
| SCHEMBL4636262 | 0.84 | FOS (0.54) | NPC1MAPTKMT2AMEN1CASP3 | |
| SCHEMBL31426903 | 0.84 | PDGFRB (0.55) | NPC1RXFP1MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073269-A1 | PIPERIDINE ARYL SULFONAMIDE DERIVATIVES AS KV1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011073277-A1 | PIPERIDINE ARYL SULFONAMIDE DERIVATIVES AS Kv1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | disclosed |