Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.64 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.47 |
| ▸ | WNT3A | P56704 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6888048 | 0.86 | HSD17B1 (0.53) | HPGDSJAK2JAK3CSNK1DNPC1 | |
| SCHEMBL29596804 | 0.85 | NPC1 (0.52) | NPC1RAB9AMAPTHPGDGABRA5 | |
| SCHEMBL2010059 | 0.84 | NPC1 (0.61) | TRPM8NPC1RAB9AALDH1A1L3MBTL1 | |
| SCHEMBL1222552 | 0.84 | NPC1 (0.62) | HPGDSNPC1RAB9AALDH1A1L3MBTL1 | |
| SCHEMBL1749701 | 0.82 | TP53 (0.48) | HPGDSNPC1RAB9AALDH1A1L3MBTL1 | |
| SCHEMBL4651619 | 0.81 | CYP1A2 (0.47) | NPC1RAB9AALDH1A1L3MBTL1MEN1 | |
| SCHEMBL2839767 | 0.81 | MAPT (0.60) | HPGDSTRPM8JAK2JAK3NPC1 | |
| SCHEMBL16495930 | 0.81 | HPGDS (0.53) | HPGDSNPC1CYP1A2MAPTCYP2C19 | |
| SCHEMBL16495436 | 0.81 | HPGDS (0.53) | HPGDSJAK2JAK3GABRA5WNT3A | |
| SCHEMBL13952312 | 0.81 | TRPM8 (0.54) | TRPM8ALDH1A1L3MBTL1MEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073269-A1 | PIPERIDINE ARYL SULFONAMIDE DERIVATIVES AS KV1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011073277-A1 | PIPERIDINE ARYL SULFONAMIDE DERIVATIVES AS Kv1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | disclosed |