Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 6/20 | 1.00 |
| ▸ | FTO | Q9C0B1 | 9/20 | 0.63 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28715859 | 0.85 | COMT (0.74) | COMTFTO | |
| SCHEMBL23255066 | 0.83 | COMT (0.71) | COMTFTOALDH1A1KMT2A | |
| SCHEMBL20100863 | 0.82 | COMT (0.70) | COMTFTOALDH1A1KMT2A | |
| SCHEMBL28719610 | 0.79 | COMT (0.65) | COMTFTOMAOAMAOBALDH1A1 | |
| SCHEMBL20100856 | 0.78 | FTO (1.00) | COMTFTOALDH1A1KMT2A | |
| SCHEMBL20100824 | 0.78 | FTO (1.00) | COMTFTOMAOAMAOBALDH1A1 | |
| SCHEMBL31520154 | 0.77 | FTO (0.70) | COMTFTOALDH1A1KMT2A | |
| SCHEMBL29493646 | 0.77 | COMT (0.62) | COMTFTO | |
| SCHEMBL20100874 | 0.77 | COMT (0.62) | COMTFTO | |
| SCHEMBL20100876 | 0.76 | FTO (0.78) | COMTFTO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180118665-A1 | FTO Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118665-A1 | FTO Inhibitors | FTO, ALKBH3, ALKBH1 | COMT 9/4885FTO 1/4885MAOA 162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.