Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 6/20 | 0.62 |
| ▸ | FTO | Q9C0B1 | 11/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29493646 | 1.00 | COMT (0.62) | COMTFTOEGFR | |
| SCHEMBL23255069 | 0.85 | COMT (0.43) | COMTFTO | |
| SCHEMBL20100872 | 0.84 | FTO (0.43) | COMTFTO | |
| SCHEMBL29493680 | 0.84 | FTO (0.43) | COMTFTO | |
| SCHEMBL20100876 | 0.80 | FTO (0.78) | COMTFTOEGFR | |
| SCHEMBL20100862 | 0.77 | COMT (1.00) | COMTFTO | |
| SCHEMBL28715859 | 0.76 | COMT (0.74) | COMTFTO | |
| SCHEMBL20100828 | 0.74 | COMT (0.72) | COMTFTO | |
| SCHEMBL29493647 | 0.74 | COMT (0.72) | COMTFTO | |
| SCHEMBL31520154 | 0.74 | FTO (0.70) | COMTFTO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107922316-B | FTO inhibitors | 北京生命科学研究所 | 2022-04-08 | — | — | CN | disclosed |
| US-20180118665-A1 | FTO Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118665-A1 | FTO Inhibitors | FTO, ALKBH3, ALKBH1 | COMT 9/4885FTO 1/4885EGFR 4024/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.