Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PPIA | P62937 | 2/20 | 0.38 |
| ▸ | AKT1 | P31749 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10188411 | 0.91 | HPGD (0.44) | SMN1; SMN2HTTHPGDMEN1ALDH1A1 | |
| Water SCHEMBL28917805 | 0.90 | HPGD (0.43) | SMN1; SMN2HTTHPGDMEN1ALDH1A1 | |
| SCHEMBL20101966 | 0.89 | SMN1; SMN2 (0.38) | SMN1; SMN2HTTHPGDMEN1ALDH1A1 | |
| SCHEMBL21185002 | 0.89 | HTT (0.44) | SMN1; SMN2HTTHPGDMEN1ALDH1A1 | |
| SCHEMBL23418413 | 0.86 | BRD4 (0.40) | SMN1; SMN2HTTHPGDMEN1ALDH1A1 | |
| SCHEMBL22508485 | 0.86 | SMN1; SMN2 (0.41) | SMN1; SMN2HTTHPGDMEN1ALDH1A1 | |
| SCHEMBL23223246 | 0.84 | SYK (0.39) | SMN1; SMN2HTTHPGDMEN1ALDH1A1 | |
| SCHEMBL25024299 | 0.84 | MKNK2 (0.40) | ALDH1A1KMT2ACRHBPCRHR2GAA | |
| SCHEMBL25750671 | 0.84 | HTT (0.40) | SMN1; SMN2HTTHPGDMEN1ALDH1A1 | |
| SCHEMBL31084272 | 0.83 | HTT (0.43) | SMN1; SMN2HTTHPGDMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114907365-B | Influenza virus inhibitor and application thereof | 扬子江药业集团有限公司 | 2023-12-01 | — | — | CN | disclosed |
| CN-117120441-A | Influenza virus inhibitor and application thereof | 扬子江药业集团有限公司 | 2023-11-24 | — | — | CN | disclosed |
| US-20230287004-A1 | SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF | SHIONOGI & CO., LTD. (JP) | 2023-09-14 | — | — | US | disclosed |
| US-20230287004-A1 | SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF | SHIONOGI & CO., LTD. (JP) | 2023-09-14 | — | — | US | disclosed |
| US-20230144122-A1 | PYRIDONE DERIVATIVE CRYSTAL FORM AND PREPARATION METHOD AND APPLICATION THEREFOR | JIANGXI CAISHI PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) | 2023-05-11 | — | — | US | disclosed |
| US-20230144122-A1 | PYRIDONE DERIVATIVE CRYSTAL FORM AND PREPARATION METHOD AND APPLICATION THEREFOR | JIANGXI CAISHI PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) | 2023-05-11 | — | — | US | disclosed |
| US-20230040262-A1 | STEREOSELECTIVE PROCESS FOR PREPARING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2023-02-09 | — | — | US | disclosed |
| WO-2022171198-A1 | INFLUENZA VIRUS INHIBITOR AND USE THEREOF | 扬子江药业集团有限公司 | 2022-08-18 | — | — | WO | disclosed |
| CN-114907365-A | Influenza virus inhibitor and application thereof | 扬子江药业集团有限公司 | 2022-08-16 | — | — | CN | disclosed |
| US-20220177487-A1 | FUSED POLYCYCLIC PYRIDONE COMPOUNDS AS INFLUENZA VIRUS REPLICATION INHIBITORS | NIKANG THERAPEUTICS, INC. | 2022-06-09 | — | — | US | disclosed |
| EP-3686201-A1 | INFLUENZA VIRUS REPLICATION INHIBITOR AND USE THEREOF | Sunshine Lake Pharma Co., Ltd. (CN) | 2020-07-29 | — | — | EP | disclosed |
| US-10633397-B2 | Substituted polycyclic pyridone derivatives and prodrugs thereof | SHIONOGI & CO., LTD. (JP) | 2020-04-28 | — | — | US | disclosed |
| WO-2019196891-A1 | POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF | 安帝康（无锡）生物科技有限公司 | 2019-10-17 | — | — | WO | disclosed |
| US-10392406-B2 | Substituted polycyclic pyridone derivatives and prodrugs thereof | SHIONOGI & CO., LTD. (JP) | 2019-08-27 | — | — | US | disclosed |
| WO-2019141179-A1 | PYRIDONE DERIVATIVE, COMPOSITION THEREOF AND APPLICATION THEREOF AS ANTI-INFLUENZA DRUG | 银杏树药业(苏州)有限公司 | 2019-07-25 | — | — | WO | disclosed |
| US-20190169206-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUG THEREOF | SHIONOGI & CO., LTD. (JP) | 2019-06-06 | — | — | US | disclosed |
| US-10294241-B2 | — | — | 2019-05-21 | — | — | US | disclosed |
| US-20190112315-A1 | SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF | SHIONOGI & CO., LTD. (JP) | 2019-04-18 | — | — | US | disclosed |
| US-20180118760-A1 | SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF | SHIONOGI & CO., LTD. (JP) | 2018-05-03 | — | — | US | disclosed |
| US-20180118760-A1 | SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF | SHIONOGI & CO., LTD. (JP) | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230040262-A1 | STEREOSELECTIVE PROCESS FOR PREPARING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES | RNGTT, CPSF6, RNASEL | SMN1; SMN2 2614/4885HTT 4786/4885HPGD 1499/4885 |
| US-20230287004-A1 | SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF | C3AR1, NR4A1, HAVCR2 | SMN1; SMN2 3547/4885HTT 4544/4885HPGD 2908/4885 |
| US-20190169206-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUG THEREOF | TYMP, PNP, CYP3A4 | SMN1; SMN2 1950/4885HTT 3721/4885HPGD 396/4885 |
| US-10294241-B2 | — | C3AR1, HAVCR2, NR4A1 | SMN1; SMN2 3158/4885HTT 3185/4885HPGD 4853/4885 |
| US-10633397-B2 | Substituted polycyclic pyridone derivatives and prodrugs thereof | C3AR1, NR4A1, HAVCR2 | SMN1; SMN2 3547/4885HTT 4544/4885HPGD 2908/4885 |
| US-10392406-B2 | Substituted polycyclic pyridone derivatives and prodrugs thereof | C3AR1, NR4A1, HAVCR2 | SMN1; SMN2 3547/4885HTT 4544/4885HPGD 2908/4885 |
| US-20190112315-A1 | SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF | C3AR1, NR4A1, HAVCR2 | SMN1; SMN2 3547/4885HTT 4544/4885HPGD 2908/4885 |
| US-20220177487-A1 | FUSED POLYCYCLIC PYRIDONE COMPOUNDS AS INFLUENZA VIRUS REPLICATION INHIBITORS | PDXK, PNPO, CDKN1A | SMN1; SMN2 3213/4885HTT 4698/4885HPGD 810/4885 |
| US-20180118760-A1 | SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF | C3AR1, NR4A1, HAVCR2 | SMN1; SMN2 3547/4885HTT 4544/4885HPGD 2908/4885 |
| US-20230144122-A1 | PYRIDONE DERIVATIVE CRYSTAL FORM AND PREPARATION METHOD AND APPLICATION THEREFOR | CYP51A1, CYP2F1, SFRP1 | SMN1; SMN2 2917/4885HTT 4118/4885HPGD 816/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.