Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.54 |
| ▸ | MTOR | P42345 | 9/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4992754 | 0.90 | PIK3CA (0.65) | SMN1; SMN2NPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL23163834 | 0.79 | PIK3CA (0.51) | SMN1; SMN2NPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL12264967 | 0.78 | KMT2A (0.62) | SMN1; SMN2PIK3CAGAAPKMHTT | |
| SCHEMBL20102972 | 0.75 | ALDH1A1 (0.74) | SMN1; SMN2NPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL2809356 | 0.75 | GRM1 (0.54) | SMN1; SMN2NPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL16058862 | 0.74 | SMN1; SMN2 (0.47) | SMN1; SMN2PIK3CAMTORGAAPKM | |
| SCHEMBL3987772 | 0.74 | SRC (0.50) | SMN1; SMN2ALDH1A1PIK3CAMTORGAA | |
| SCHEMBL24955563 | 0.73 | PIK3CA (0.51) | PIK3CAMTOR | |
| SCHEMBL4847825 | 0.73 | PRKDC (0.50) | SMN1; SMN2NPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL3989353 | 0.72 | MTOR (0.55) | SMN1; SMN2PIK3CAMTORGAAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230181589-A1 | PRMT5 INHIBITORS FOR OCULAR THERAPY | NATIONAL INSTITUTES OF HEALTH | 2023-06-15 | — | — | US | disclosed |
| US-11034689-B2 | Small molecule protein arginine methyltransferase 5 (PRMT5) inhibitors and methods of treatment | THE TRUSTEES OF INDIANA UNIVERSITY (US) | 2021-06-15 | — | — | US | disclosed |
| US-20200062745-A1 | Small Molecule Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors and Methods of Treatment | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2020-02-27 | — | — | US | disclosed |
| WO-2018081451-A1 | SMALL MOLECULE PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) INHIBITORS AND METHODS OF TREATMENT | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2018-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11034689-B2 | Small molecule protein arginine methyltransferase 5 (PRMT5) inhibitors and methods of treatment | PRMT5, PRMT1, PRMT3 | SMN1; SMN2 2595/4885NPC1 3265/4885RAB9A 2055/4885 |
| US-20200062745-A1 | Small Molecule Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors and Methods of Treatment | PRMT5, PRMT1, PRMT3 | SMN1; SMN2 2595/4885NPC1 3265/4885RAB9A 2055/4885 |
| US-20230181589-A1 | PRMT5 INHIBITORS FOR OCULAR THERAPY | PRMT5, PRMT1, PRMT3 | SMN1; SMN2 3270/4885NPC1 3227/4885RAB9A 1616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.