Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 6/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.40 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.39 |
| ▸ | TNKS | O95271 | 3/20 | 0.37 |
| ▸ | CNR1 | P21554 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20103438 | 0.95 | LMNA (0.44) | LMNAESR1TNKS2HPGDPDE4B | |
| SCHEMBL20103204 | 0.89 | PDE4B (0.44) | TNKS2HPGDPDE4BCRHR1CRHR2 | |
| SCHEMBL20103478 | 0.84 | TNKS2 (0.46) | TNKS2PDE4BP2RX7TNKSMEN1 | |
| SCHEMBL20103113 | 0.83 | TNKS2 (0.42) | LMNAESR1TNKS2HPGDPDE4B | |
| SCHEMBL20103178 | 0.83 | TNKS2 (0.42) | LMNAESR1TNKS2HPGDPDE4B | |
| SCHEMBL20103119 | 0.81 | PDE4B (0.44) | LMNAESR1TNKS2PDE4BTNKS | |
| SCHEMBL20118132 | 0.81 | LMNA (0.46) | LMNAESR1TNKS2HPGDPDE4B | |
| SCHEMBL20103186 | 0.81 | PDE4B (0.45) | LMNAESR1TNKS2PDE4BTNKS | |
| SCHEMBL18208145 | 0.80 | MAP3K5 (0.44) | HPGDPDE4BCRHR1CRHR2P2RX7 | |
| SCHEMBL18208148 | 0.80 | MAP3K5 (0.44) | HPGDPDE4BCRHR1CRHR2P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018078005-A1 | AMIDO-SUBSTITUTED AZASPIRO DERIVATIVES AS TANKYRASE INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-03 | — | — | WO | disclosed |