Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | PARP1 | P09874 | 6/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | F10 | P00742 | 2/20 | 0.35 |
| ▸ | PPOX | P50336 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24928510 | 0.83 | HSD17B10 (0.44) | HPGDPARP1HSD17B10AKR1C3ALDH1A1 | |
| SCHEMBL20103445 | 0.81 | P2RX7 (0.52) | PARP1ALDH1A1POLBP2RX7 | |
| SCHEMBL22816936 | 0.76 | HSD17B10 (0.42) | HPGDHSD17B10AKR1C3ALDH1A1POLB | |
| SCHEMBL6329653 | 0.75 | PARP1 (0.43) | PARP1HSD17B10ALDH1A1F10 | |
| SCHEMBL20103114 | 0.75 | PARP1 (0.38) | HPGDPARP1AKR1C3ALDH1A1L3MBTL1 | |
| SCHEMBL22816934 | 0.74 | ALDH1A1 (0.60) | HSD17B10ALDH1A1POLB | |
| SCHEMBL20103130 | 0.73 | ADRA1A (0.48) | HSD17B10AKR1C3ALDH1A1POLBL3MBTL1 | |
| SCHEMBL11181693 | 0.73 | HSD17B10 (0.53) | HPGDHSD17B10AKR1C3ALDH1A1POLB | |
| SCHEMBL8305486 | 0.73 | HSD17B10 (0.45) | HSD17B10AKR1C3ALDH1A1POLBF10 | |
| SCHEMBL85665 | 0.73 | ALDH1A1 (0.44) | PARP1HSD17B10ALDH1A1POLBF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018078005-A1 | AMIDO-SUBSTITUTED AZASPIRO DERIVATIVES AS TANKYRASE INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-03 | — | — | WO | disclosed |