Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 12/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TNKS | O95271 | 7/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20103438 | 0.84 | LMNA (0.44) | TNKS2LMNAESR1HPGDTNKS | |
| SCHEMBL20103162 | 0.83 | LMNA (0.43) | TNKS2LMNAESR1HPGDTNKS | |
| SCHEMBL20103204 | 0.78 | PDE4B (0.44) | TNKS2HPGDTNKSPDE4BCRHR1 | |
| SCHEMBL20118132 | 0.78 | LMNA (0.46) | TNKS2LMNAESR1HPGDTNKS | |
| SCHEMBL20118213 | 0.76 | LMNA (0.42) | TNKS2LMNAESR1HPGDTNKS | |
| SCHEMBL20103113 | 0.74 | TNKS2 (0.42) | TNKS2LMNAESR1HPGDTNKS | |
| SCHEMBL20103478 | 0.72 | TNKS2 (0.46) | TNKS2TNKSPDE4BP2RX7SMN1; SMN2 | |
| SCHEMBL20103186 | 0.72 | PDE4B (0.45) | TNKS2LMNAESR1TNKSPDE4B | |
| SCHEMBL20103119 | 0.71 | PDE4B (0.44) | TNKS2LMNAESR1TNKSPDE4B | |
| SCHEMBL20139011 | 0.70 | LMNA (0.52) | TNKS2LMNAESR1HPGDPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018078005-A1 | AMIDO-SUBSTITUTED AZASPIRO DERIVATIVES AS TANKYRASE INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-03 | — | — | WO | disclosed |