Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 7/20 | 0.44 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL368032 | 0.85 | CYP1A2 (0.45) | L3MBTL1NR1H2CNR2ALDH1A1MAPT | |
| SCHEMBL14838247 | 0.84 | CYP1A2 (0.47) | L3MBTL1NR1H2CNR2ALDH1A1MAPT | |
| SCHEMBL133464 | 0.84 | ALDH1A1 (0.57) | L3MBTL1NR1H2CNR2ALDH1A1MAPT | |
| SCHEMBL14300652 | 0.83 | CYP1A2 (0.46) | L3MBTL1NR1H2CNR2ALDH1A1MAPT | |
| SCHEMBL6737502 | 0.83 | BRD4 (0.42) | SMN1; SMN2NR1H2CNR2ALDH1A1MAPT | |
| SCHEMBL4065436 | 0.82 | CNR2 (0.46) | L3MBTL1NR1H2CNR2ALDH1A1MAPT | |
| SCHEMBL25168045 | 0.82 | L3MBTL1 (0.46) | L3MBTL1NR1H2CNR2ALDH1A1MAPT | |
| SCHEMBL3447293 | 0.82 | CNR2 (0.46) | SMN1; SMN2L3MBTL1NR1H2CNR2ALDH1A1 | |
| SCHEMBL25736832 | 0.82 | L3MBTL1 (0.46) | L3MBTL1NR1H2CNR2ALDH1A1MAPT | |
| SCHEMBL17329317 | 0.82 | NPC1 (0.56) | SMN1; SMN2L3MBTL1NR1H2CNR2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115768761-B | Novel benzimidazole derivatives | 卡尔那生物科学株式会社 | 2025-02-25 | — | — | CN | disclosed |
| US-20240279205-A1 | NOVEL BENZIMIDAZOLE DERIVATIVE | CARNA BIOSCIENCES, INC. (JP) | 2024-08-22 | — | — | US | disclosed |
| CN-112313222-B | Tetrahydroisoquinoline derivative, preparation method and application thereof | 浙江海正药业股份有限公司 | 2024-01-26 | — | — | CN | disclosed |
| CN-115768761-A | Novel benzimidazole derivatives | 卡尔那生物科学株式会社 | 2023-03-07 | — | — | CN | disclosed |
| EP-4129406-A1 | NOVEL BENZIMIDAZOLE DERIVATIVE | Carna Biosciences, Inc. (JP) | 2023-02-08 | — | — | EP | disclosed |
| US-11384097-B2 | Tetrahydroisoquinoline derivative, preparation method therefor and use thereof | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2022-07-12 | — | — | US | disclosed |
| US-20210277021-A1 | TETRAHYDROISOQUINOLINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2021-09-09 | — | — | US | disclosed |
| CN-112313222-A | Tetrahydroisoquinoline derivatives, preparation method and application thereof | 浙江海正药业股份有限公司 | 2021-02-02 | — | — | CN | disclosed |
| EP-3353167-B1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-06-24 | — | — | EP | disclosed |
| WO-2019242599-A1 | TETRAHYDRO ISOQUINOLINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | 浙江海正药业股份有限公司 | 2019-12-26 | — | — | WO | disclosed |
| EP-1098894-A1 | FKBP INHIBITORS | Pfizer Limited (GB) | 2001-05-16 | — | — | EP | disclosed |
| EP-1087962-A1 | PREPARATION OF HETEROARYL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2001-04-04 | — | — | EP | disclosed |
| EP-0977740-A4 | METHODS FOR SYNTHESIZING 2-SUBSTITUTED IMIDAZOLES | SEPRACOR INC (US) | 2001-01-17 | — | — | EP | disclosed |
| US-6166011-A | FKBP inhibitors | PFIZER INC (US) | 2000-12-26 | — | — | US | disclosed |
| EP-0977740-A1 | METHODS FOR SYNTHESIZING 2-SUBSTITUTED IMIDAZOLES | SEPRACOR, INC. (US) | 2000-02-09 | — | — | EP | disclosed |
| WO-2000005232-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER LIMITED (GB) | 2000-02-03 | — | — | WO | disclosed |
| WO-2000005231-A1 | FKBP INHIBITORS | PFIZER LIMITED (GB) | 2000-02-03 | — | — | WO | disclosed |
| WO-1999065896-A1 | PREPARATION OF HETEROARYL COMPOUNDS | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
| WO-1998046571-A1 | METHODS FOR SYNTHESIZING 2-SUBSTITUTED IMIDAZOLES | SEPRACOR INC. (US) | 1998-10-22 | — | — | WO | disclosed |
| US-5817823-A | ALKYLATION OF AN IMIDAZOLE COMPOUND; COUPLING WITH NUCLEOPHILIC COMPOUND | SEPRACOR INC. (US) | 1998-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11384097-B2 | Tetrahydroisoquinoline derivative, preparation method therefor and use thereof | AGTR2, AGTR1, AVPR2 | SMN1; SMN2 4751/4885L3MBTL1 4864/4885NR1H2 228/4885 |
| US-20240279205-A1 | NOVEL BENZIMIDAZOLE DERIVATIVE | STING1, IRF3, TBK1 | SMN1; SMN2 2934/4885L3MBTL1 1430/4885NR1H2 3318/4885 |
| US-20210277021-A1 | TETRAHYDROISOQUINOLINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | AGTR2, AGTR1, AVPR2 | SMN1; SMN2 4751/4885L3MBTL1 4864/4885NR1H2 228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.