Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 3/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 3/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29493662 | 1.00 | MCL1 (0.50) | MCL1MAPK14NAMPTJAK2JAK1 | |
| SCHEMBL7970340 | 0.80 | SMN1; SMN2 (0.63) | MCL1POLBSMN1; SMN2HPGDALOX15 | |
| SCHEMBL29623938 | 0.80 | SMN1; SMN2 (0.63) | MCL1POLBSMN1; SMN2HPGDALOX15 | |
| SCHEMBL8819 | 0.80 | NAMPT (0.52) | MAPK14NAMPTHPGDSPOLBCHRM4 | |
| SCHEMBL2266663 | 0.78 | MCL1 (0.70) | MCL1SMN1; SMN2HSD17B10 | |
| SCHEMBL22501568 | 0.77 | NAMPT (0.52) | MAPK14NAMPTHPGDSPOLBCHRM4 | |
| SCHEMBL28124071 | 0.77 | NAMPT (0.50) | MAPK14NAMPTHPGDSPOLBCHRM4 | |
| SCHEMBL19169741 | 0.76 | HPGD (0.48) | MAPK14NAMPTHPGDSPOLBCHRM4 | |
| SCHEMBL19116342 | 0.76 | HPGD (0.48) | MAPK14NAMPTHPGDSPOLBCHRM4 | |
| SCHEMBL18343422 | 0.76 | NPSR1 (0.53) | MAPK14NAMPTHPGDSCHRM4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107922316-B | FTO inhibitors | 北京生命科学研究所 | 2022-04-08 | — | — | CN | disclosed |
| EP-3885337-A1 | FTO INHIBITORS | National Institute Of Biological Sciences, Beijing (CN) | 2021-09-29 | — | — | EP | disclosed |
| US-10988440-B2 | FTO inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-04-27 | — | — | US | disclosed |
| EP-3303283-B1 | FTO INHIBITORS | NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING (CN) | 2021-04-21 | — | — | EP | disclosed |
| US-20200148628-A1 | FTO Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2020-05-14 | — | — | US | disclosed |
| US-20180118665-A1 | FTO Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118665-A1 | FTO Inhibitors | FTO, ALKBH3, ALKBH1 | MCL1 4344/4885MAPK14 3705/4885NAMPT 601/4885 |
| US-20200148628-A1 | FTO Inhibitors | FTO, ALKBH3, ALKBH1 | MCL1 4344/4885MAPK14 3705/4885NAMPT 601/4885 |
| US-10988440-B2 | FTO inhibitors | FTO, ALKBH3, ALKBH1 | MCL1 4344/4885MAPK14 3705/4885NAMPT 601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.