Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 10/20 | 0.53 |
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.44 |
| ▸ | DRD1 | P21728 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20105033 | 0.92 | CCNB2 (0.48) | CNR1HTR2ACHRM2ADRA2ACHRM1 | |
| SCHEMBL20105030 | 0.89 | HTR2A (0.56) | CNR1HTR2ACHRM2ADRA2ACHRM1 | |
| SCHEMBL20105040 | 0.88 | MAPT (0.52) | CNR1HTR2ACHRM2ADRA2ACHRM1 | |
| SCHEMBL20105011 | 0.87 | CNR1 (0.53) | CNR1OPRM1MAPTLMNAGAA | |
| SCHEMBL20105038 | 0.81 | CHRM2 (0.60) | CNR1HTR2ACHRM2ADRA2ACHRM1 | |
| SCHEMBL20105020 | 0.80 | HTR2A (0.44) | CNR1HTR2ACHRM2ADRA2ACHRM1 | |
| SCHEMBL21272281 | 0.80 | CHRM2 (0.52) | CNR1HTR2ACHRM2ADRA2ACHRM1 | |
| SCHEMBL20105008 | 0.79 | CCNB2 (0.46) | CNR1OPRM1MAPTLMNAGAA | |
| SCHEMBL20105026 | 0.77 | CHRM2 (0.58) | CNR1HTR2ACHRM2ADRA2ACHRM1 | |
| SCHEMBL5262177 | 0.77 | MAPT (0.56) | CNR1HTR2AKCNH2HTR2CMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10597362-B2 | 3-aminoalkylated indole derivative, method for the preparation thereof, and pharmaceutical composition comprising the same | SEOUL NATIONAL UNIVERSITY HOSPITAL (KR) | 2020-03-24 | — | — | US | claimed |
| US-20190256465-A1 | 3-AMINOALKYLATED INDOLE DERIVATIVE, METHOD FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | SEOUL NATIONAL UNIVERSITY HOSPITAL (KR) | 2019-08-22 | — | — | US | claimed |
| US-10597362-B2 | 3-aminoalkylated indole derivative, method for the preparation thereof, and pharmaceutical composition comprising the same | SEOUL NATIONAL UNIVERSITY HOSPITAL (KR) | 2020-03-24 | — | — | US | disclosed |
| US-20190256465-A1 | 3-AMINOALKYLATED INDOLE DERIVATIVE, METHOD FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | SEOUL NATIONAL UNIVERSITY HOSPITAL (KR) | 2019-08-22 | — | — | US | disclosed |
| US-20190256465-A1 | 3-AMINOALKYLATED INDOLE DERIVATIVE, METHOD FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | SEOUL NATIONAL UNIVERSITY HOSPITAL (KR) | 2019-08-22 | — | — | US | disclosed |
| WO-2018080215-A1 | 3-AMINO ALKYLATED INDOLE DERIVATIVE, METHOD FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2018-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10597362-B2 | 3-aminoalkylated indole derivative, method for the preparation thereof, and pharmaceutical composition comprising the same | IDO1, TPH1, AADAT | CNR1 457/4885HTR2A 136/4885CHRM2 1620/4885 |
| US-20190256465-A1 | 3-AMINOALKYLATED INDOLE DERIVATIVE, METHOD FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | IDO1, TPH1, AADAT | CNR1 457/4885HTR2A 136/4885CHRM2 1620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.