SCHEMBL2010535

SCHEMBL2010535

C[CH]Cc1cccc(C)n1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR1 P32246 1/20 0.44
CCR8 P51685 1/20 0.44
NOS3 P29474 1/20 0.41
NOS2 P35228 1/20 0.41
SMN1; SMN2 Q16637 3/20 0.41
KDM1A O60341 1/20 0.38
MAOA P21397 1/20 0.38
MAOB P27338 1/20 0.38
MEN1 O00255 4/20 0.37
KMT2A Q03164 4/20 0.37
OPRM1 P35372 1/20 0.37
OPRD1 P41143 1/20 0.37
ALDH1A1 P00352 3/20 0.37
RAB9A P51151 3/20 0.37
NPC1 O15118 2/20 0.37
GRM5 P41594 2/20 0.37
HDAC6 Q9UBN7 2/20 0.37
KDM4E B2RXH2 2/20 0.37
CYP3A4 P08684 2/20 0.37
CYP2D6 P10635 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13879249 0.83 NOS2 (0.43) CCR1CCR8NOS3NOS2SMN1; SMN2
SCHEMBL247492 0.81 SMN1; SMN2 (0.44) CCR1CCR8NOS3NOS2SMN1; SMN2
SCHEMBL17429701 0.81 CCR1 (0.43) CCR1CCR8NOS3NOS2SMN1; SMN2
SCHEMBL21386765 0.79 CCR1 (0.38) CCR1CCR8NOS3NOS2SMN1; SMN2
SCHEMBL943326 0.77
SCHEMBL24916774 0.77 CCR1 (0.52) CCR1CCR8NOS3NOS2SMN1; SMN2
SCHEMBL14082023 0.77 CCR1 (0.52) CCR1CCR8NOS3NOS2SMN1; SMN2
SCHEMBL30201993 0.77 CCR1 (0.52) CCR1CCR8NOS3NOS2SMN1; SMN2
SCHEMBL526379 0.76 CCR1 (0.39) CCR1CCR8NOS3NOS2SMN1; SMN2
SCHEMBL526380 0.76 CCR1 (0.39) CCR1CCR8NOS3NOS2SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011073269-A1 PIPERIDINE ARYL SULFONAMIDE DERIVATIVES AS KV1.3 MODULATORS EVOTEC AG (DE) 2011-06-23 WO disclosed
WO-2011073276-A1 BENZOXAZINE ARYL SULFONAMIDE DERIVATIVES AS KV1.3 MODULATORS EVOTEC AG (DE) 2011-06-23 WO disclosed