Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20101966 | 0.80 | SMN1; SMN2 (0.38) | SMN1; SMN2MEN1ALDH1A1KMT2AHPGD | |
| SCHEMBL20101965 | 0.77 | SMN1; SMN2 (0.43) | SMN1; SMN2MEN1ALDH1A1KMT2AHPGD | |
| SCHEMBL21627126 | 0.74 | LMNA (0.44) | SMN1; SMN2MEN1ALDH1A1KMT2AHPGD | |
| SCHEMBL22997083 | 0.72 | LMNA (0.46) | SMN1; SMN2MEN1ALDH1A1KMT2AHPGD | |
| SCHEMBL20101953 | 0.71 | SMN1; SMN2 (0.42) | SMN1; SMN2MEN1ALDH1A1KMT2AHPGD | |
| SCHEMBL20101954 | 0.67 | SMN1; SMN2 (0.50) | SMN1; SMN2MEN1ALDH1A1KMT2AHPGD | |
| SCHEMBL10188411 | 0.67 | HPGD (0.44) | SMN1; SMN2MEN1ALDH1A1KMT2AHPGD | |
| SCHEMBL20101972 | 0.67 | GAA (0.52) | SMN1; SMN2HPGDNPC1TDP1GAA | |
| SCHEMBL29062597 | 0.67 | HTT (0.58) | SMN1; SMN2MEN1ALDH1A1KMT2AHPGD | |
| Water SCHEMBL28917805 | 0.66 | HPGD (0.43) | SMN1; SMN2MEN1ALDH1A1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230040262-A1 | STEREOSELECTIVE PROCESS FOR PREPARING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2023-02-09 | — | — | US | disclosed |
| US-20200361958-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUG THEREOF | SHIONOGI & CO., LTD. (JP) | 2020-11-19 | — | — | US | disclosed |
| EP-3693373-A1 | METHOD FOR STEREOSELECTIVELY PRODUCING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVE | Shionogi&Co., Ltd. (JP) | 2020-08-12 | — | — | EP | disclosed |
| US-20200247818-A1 | STEREOSELECTIVE PROCESS FOR PREPARING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2020-08-06 | — | — | US | disclosed |
| US-10392406-B2 | Substituted polycyclic pyridone derivatives and prodrugs thereof | SHIONOGI & CO., LTD. (JP) | 2019-08-27 | — | — | US | disclosed |
| US-10294241-B2 | — | — | 2019-05-21 | — | — | US | disclosed |
| US-20180118760-A1 | SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF | SHIONOGI & CO., LTD. (JP) | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200361958-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUG THEREOF | TYMP, PNP, CYP3A4 | SMN1; SMN2 1950/4885MEN1 2519/4885ALDH1A1 1653/4885 |
| US-20200247818-A1 | STEREOSELECTIVE PROCESS FOR PREPARING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES | RNGTT, CPSF6, ENDOD1 | SMN1; SMN2 2630/4885MEN1 3665/4885ALDH1A1 1645/4885 |
| US-20230040262-A1 | STEREOSELECTIVE PROCESS FOR PREPARING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES | RNGTT, CPSF6, RNASEL | SMN1; SMN2 2614/4885MEN1 3650/4885ALDH1A1 1711/4885 |
| US-10294241-B2 | — | C3AR1, HAVCR2, NR4A1 | SMN1; SMN2 3158/4885MEN1 2550/4885ALDH1A1 2705/4885 |
| US-10392406-B2 | Substituted polycyclic pyridone derivatives and prodrugs thereof | C3AR1, NR4A1, HAVCR2 | SMN1; SMN2 3547/4885MEN1 2563/4885ALDH1A1 1319/4885 |
| US-20180118760-A1 | SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF | C3AR1, NR4A1, HAVCR2 | SMN1; SMN2 3547/4885MEN1 2563/4885ALDH1A1 1319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.