Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9039446 | 0.75 | UHRF1 (0.43) | UHRF1CHRM3PDE4APDE4BPDE4C | |
| SCHEMBL6455478 | 0.71 | KDM4E (0.60) | KDM4ENUDT1NOS3NOS1NOS2 | |
| SCHEMBL31712947 | 0.67 | UHRF1 (0.46) | UHRF1CHRM3PDE4APDE4BPDE4C | |
| SCHEMBL13686502 | 0.66 | HRH4 (0.49) | CHRM3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL15757353 | 0.66 | NUDT1 (0.64) | UHRF1NUDT1 | |
| SCHEMBL9038007 | 0.66 | UHRF1 (0.39) | UHRF1KDR | |
| SCHEMBL12481059 | 0.66 | KDR (0.45) | UHRF1KDRNOS3NOS1NOS2 | |
| SCHEMBL16916462 | 0.64 | UHRF1 (0.43) | UHRF1CHRM3PDE4APDE4BPDE4C | |
| SCHEMBL9038638 | 0.64 | MPO (0.46) | UHRF1KDR | |
| SCHEMBL9038000 | 0.64 | GRM5 (0.41) | UHRF1KDM4EKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180118721-A1 | PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118721-A1 | PYRIMIDINE DERIVATIVES | MTHFD1, TYMS, DPYD | UHRF1 931/4885CHRM3 4671/4885PDE4A 2589/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.