Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 14/20 | 1.00 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1576638 | 0.80 | NUDT1 (0.65) | NUDT1PDPK1TGFBR1 | |
| SCHEMBL7718036 | 0.79 | NUDT1 (0.66) | NUDT1PDPK1TGFBR1AURKAAURKB | |
| SCHEMBL9178127 | 0.79 | NUDT1 (0.66) | NUDT1PDPK1TGFBR1 | |
| SCHEMBL9182270 | 0.79 | NUDT1 (0.66) | NUDT1PDPK1TGFBR1AURKAAURKB | |
| SCHEMBL11038442 | 0.79 | NUDT1 (0.66) | NUDT1HTR6 | |
| SCHEMBL7717516 | 0.79 | NUDT1 (0.66) | NUDT1HTR6 | |
| SCHEMBL7164892 | 0.77 | NUDT1 (0.62) | NUDT1 | |
| SCHEMBL20109486 | 0.77 | NUDT1 (0.62) | NUDT1PDPK1TGFBR1AURKAROCK1 | |
| SCHEMBL15757689 | 0.75 | NUDT1 (0.60) | NUDT1HTR6PDPK1TGFBR1AURKA | |
| SCHEMBL7522734 | 0.74 | TLR8 (0.65) | NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180118721-A1 | PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118721-A1 | PYRIMIDINE DERIVATIVES | MTHFD1, TYMS, DPYD | NUDT1 10/4885HTR6 3568/4885PDPK1 2092/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.