Sugi Predict

Sugi Predict / Compounds / SCHEMBL20111376

SCHEMBL20111376

SCHEMBL20111376

CC(O)(CC(=O)Nc1nc2ccc(C(F)(F)F)cc2n1C1(C)CCC1)c1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CSNK1D P48730 2/20 0.39
▸ MCHR1 Q99705 2/20 0.39
▸ S1PR1 P21453 2/20 0.37
▸ ACSS2 Q9NR19 2/20 0.36
▸ EGFR P00533 2/20 0.36
▸ PIN1 Q13526 1/20 0.36
▸ MAP3K7 O43318 2/20 0.36
▸ IRAK4 Q9NWZ3 2/20 0.36
▸ IRAK1 P51617 1/20 0.36
▸ OPRK1 P41145 2/20 0.35
▸ LMNA P02545 1/20 0.35
▸ MAPT P10636 1/20 0.35
▸ KDM4E B2RXH2 1/20 0.35
▸ ALDH1A1 P00352 1/20 0.35
▸ POLB P06746 1/20 0.35
▸ OPRM1 P35372 1/20 0.35
▸ OPRD1 P41143 1/20 0.35
▸ OPRL1 P41146 1/20 0.35
▸ ROCK2 O75116 2/20 0.35
▸ PHGDH O43175 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18791934 1.00 CSNK1D (0.39) CSNK1DMCHR1S1PR1ACSS2EGFR
SCHEMBL18791666 1.00 CSNK1D (0.39) CSNK1DMCHR1S1PR1ACSS2EGFR
SCHEMBL18193361 0.93 RORC (0.39) CSNK1DMCHR1S1PR1ACSS2IRAK1
SCHEMBL18791667 0.90 CSNK1D (0.42) CSNK1DMCHR1S1PR1EGFRMAPT
SCHEMBL21771752 0.89 CSNK1D (0.38) CSNK1DMCHR1S1PR1EGFRPIN1
SCHEMBL21771751 0.89 S1PR1 (0.38) CSNK1DMCHR1S1PR1ACSS2EGFR
SCHEMBL26021017 0.89 S1PR1 (0.38) CSNK1DMCHR1S1PR1ACSS2EGFR
SCHEMBL20111113 0.88 ACSS2 (0.38) MCHR1ACSS2
SCHEMBL18791928 0.88 ACSS2 (0.38) MCHR1ACSS2
SCHEMBL18791929 0.88 ACSS2 (0.38) MCHR1ACSS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230000831-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE CHANNEL BIOSCIENCES, LLC 2023-01-05 — — US disclosed
US-20210130299-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2021-05-06 — — US disclosed
US-20200062714-A1 BENZOIMIDAZOL-1,2-YL AMIDES AS Kv7 CHANNEL ACTIVATORS CHANNEL BIOSCIENCES, LLC 2020-02-27 — — US disclosed
WO-2018081825-A1 BENZOIMIDAZOL-1, 2-YL AMIDES AS KV7 CHANNEL ACTIVATORS KNOPP BIOSCIENCES LLC (US) 2018-05-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230000831-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE KCNA7, KCNK17, KCNAB1 CSNK1D 646/4885MCHR1 3930/4885S1PR1 2982/4885
US-20210130299-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE KCNA7, KCNK17, KCNAB1 CSNK1D 646/4885MCHR1 3930/4885S1PR1 2982/4885
US-20200062714-A1 BENZOIMIDAZOL-1,2-YL AMIDES AS Kv7 CHANNEL ACTIVATORS KCNA7, KCNJ2, KCNK17 CSNK1D 290/4885MCHR1 4581/4885S1PR1 3563/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.