SCHEMBL20111113

SCHEMBL20111113

CC(O)(CC(=O)Nc1nc2ccc(OC(F)F)cc2n1C1(C)CCC1)c1ccccc1

nearest known ligand 0.38

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ACSS2 Q9NR19 10/20 0.38
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
MCHR1 Q99705 1/20 0.35
IDH1 O75874 8/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18791928 1.00 ACSS2 (0.38) ACSS2MEN1KMT2AMCHR1IDH1
SCHEMBL18791929 1.00 ACSS2 (0.38) ACSS2MEN1KMT2AMCHR1IDH1
SCHEMBL18779281 0.89 IDH1 (0.37) MEN1KMT2AMCHR1IDH1
SCHEMBL26008057 0.89 ACSS2 (0.32) ACSS2MEN1KMT2A
SCHEMBL30315331 0.89 BRD4 (0.38) MEN1KMT2AMCHR1IDH1
SCHEMBL21354683 0.89 BRD4 (0.38) MEN1KMT2AMCHR1IDH1
SCHEMBL18791934 0.88 CSNK1D (0.39) ACSS2MCHR1
SCHEMBL20111376 0.88 CSNK1D (0.39) ACSS2MCHR1
SCHEMBL18791666 0.88 CSNK1D (0.39) ACSS2MCHR1
SCHEMBL21354586 0.86 MCHR1 (0.37) MEN1KMT2AMCHR1IDH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260062389-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE BOZIK MICHAEL E (US) 2026-03-05 US disclosed
US-12286408-B2 KV7 channel activators compositions and methods of use BIOHAVEN THERAPEUTICS LTD. (VG) 2025-04-29 US disclosed
US-20240002349-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE BIOHAVEN THERAPEUTICS LTD (US) 2024-01-04 US disclosed
US-11724990-B2 Kv7 channel activators compositions and methods of use BIOHAVEN THERAPEUTICS LTD. (VG) 2023-08-15 US disclosed
US-11724990-B2 Kv7 channel activators compositions and methods of use BIOHAVEN THERAPEUTICS LTD. (VG) 2023-08-15 US disclosed
US-11724990-B2 Kv7 channel activators compositions and methods of use BIOHAVEN THERAPEUTICS LTD. (VG) 2023-08-15 US disclosed
US-20230000831-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE CHANNEL BIOSCIENCES, LLC 2023-01-05 US disclosed
US-20230000831-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE CHANNEL BIOSCIENCES, LLC 2023-01-05 US disclosed
US-11261162-B2 KV7 channel activators compositions and methods of use KNOPP BIOSCIENCES, LLC (US) 2022-03-01 US disclosed
US-20210130299-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2021-05-06 US disclosed
US-20210130299-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2021-05-06 US disclosed
US-10851067-B2 Kv7 channel activators compositions and methods of use KNOPP BIOSCIENCES LLC (US) 2020-12-01 US disclosed
US-10851067-B2 Kv7 channel activators compositions and methods of use KNOPP BIOSCIENCES LLC (US) 2020-12-01 US disclosed
US-20200062714-A1 BENZOIMIDAZOL-1,2-YL AMIDES AS Kv7 CHANNEL ACTIVATORS CHANNEL BIOSCIENCES, LLC 2020-02-27 US disclosed
US-20190284142-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE CHANNEL BIOSCIENCES, LLC 2019-09-19 US disclosed
US-20190284142-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE CHANNEL BIOSCIENCES, LLC 2019-09-19 US disclosed
WO-2018081825-A1 BENZOIMIDAZOL-1, 2-YL AMIDES AS KV7 CHANNEL ACTIVATORS KNOPP BIOSCIENCES LLC (US) 2018-05-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11261162-B2 KV7 channel activators compositions and methods of use KCNA7, KCNK17, KCNAB1 ACSS2 2521/4885MEN1 1284/4885KMT2A 736/4885
US-20190284142-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE KCNA7, KCNK17, KCNAB1 ACSS2 2521/4885MEN1 1284/4885KMT2A 736/4885
US-11724990-B2 Kv7 channel activators compositions and methods of use KCNA7, KCNK17, KCNAB1 ACSS2 2521/4885MEN1 1284/4885KMT2A 736/4885
US-20230000831-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE KCNA7, KCNK17, KCNAB1 ACSS2 2521/4885MEN1 1284/4885KMT2A 736/4885
US-10851067-B2 Kv7 channel activators compositions and methods of use KCNA7, KCNK17, KCNAB1 ACSS2 2521/4885MEN1 1284/4885KMT2A 736/4885
US-20260062389-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE KCNA7, KCNH3, KCNA3 ACSS2 3238/4885MEN1 1825/4885KMT2A 1606/4885
US-20210130299-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE KCNA7, KCNK17, KCNAB1 ACSS2 2521/4885MEN1 1284/4885KMT2A 736/4885
US-12286408-B2 KV7 channel activators compositions and methods of use KCNA7, KCNK17, KCNAB1 ACSS2 2521/4885MEN1 1284/4885KMT2A 736/4885
US-20240002349-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE KCNA7, KCNK17, KCNAB1 ACSS2 2521/4885MEN1 1284/4885KMT2A 736/4885
US-20200062714-A1 BENZOIMIDAZOL-1,2-YL AMIDES AS Kv7 CHANNEL ACTIVATORS KCNA7, KCNJ2, KCNK17 ACSS2 928/4885MEN1 2929/4885KMT2A 507/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.