Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.38 |
| ▸ | PRKACA | P17612 | 6/20 | 0.37 |
| ▸ | GSK3B | P49841 | 6/20 | 0.37 |
| ▸ | CDK9 | P50750 | 3/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17583061 | 0.78 | HCAR1 (0.45) | HCAR1KDM4EALDH1A1MAPTGFER | |
| SCHEMBL17582727 | 0.78 | CYP11B1 (0.49) | HCAR1KDM4EALDH1A1MAPTGFER | |
| SCHEMBL2362323 | 0.78 | CYP11B2 (0.50) | HCAR1KDM4EALDH1A1MAPTGFER | |
| SCHEMBL2360920 | 0.77 | HCAR1 (0.50) | HCAR1KDM4EALDH1A1MAPTGFER | |
| SCHEMBL25920550 | 0.76 | HCAR1 (0.46) | HCAR1KDM4EALDH1A1MAPTGFER | |
| SCHEMBL14247637 | 0.75 | HCAR1 (0.48) | HCAR1KDM4EALDH1A1MAPTGFER | |
| SCHEMBL17582958 | 0.75 | CYP11B2 (0.52) | HCAR1ALDH1A1HTR6CYP11B2EGFR | |
| SCHEMBL17583042 | 0.75 | CYP11B2 (0.52) | HCAR1PRKACACDK9DYRK1ACYP11B2 | |
| SCHEMBL6198016 | 0.74 | RPS6KB1 (0.58) | HCAR1MAPTRPS6KB1PRKACAGSK3B | |
| SCHEMBL21148134 | 0.74 | RPS6KB1 (0.58) | HCAR1MAPTRPS6KB1PRKACAGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081825-A1 | BENZOIMIDAZOL-1, 2-YL AMIDES AS KV7 CHANNEL ACTIVATORS | KNOPP BIOSCIENCES LLC (US) | 2018-05-03 | — | — | WO | disclosed |