Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20111728 | 0.90 | LMNA (0.35) | LMNAGAA | |
| SCHEMBL17888259 | 0.80 | JAK1 (0.36) | JAK1LMNA | |
| SCHEMBL17888199 | 0.77 | CHRM4 (0.33) | JAK1LMNA | |
| SCHEMBL17888250 | 0.77 | CHRM4 (0.35) | JAK1LMNA | |
| SCHEMBL20111633 | 0.76 | PIK3CA (0.32) | JAK2JAK1PIK3CA | |
| SCHEMBL20111631 | 0.74 | PIK3CA (0.32) | JAK2JAK1PIK3CA | |
| SCHEMBL21732946 | 0.72 | LMNA (0.30) | LMNAGAA | |
| SCHEMBL20111628 | 0.71 | MCOLN3 (0.40) | JAK2JAK1PIK3CALMNA | |
| SCHEMBL20111632 | 0.71 | JAK2 (0.32) | JAK2JAK1PIK3CALMNAGAA | |
| SCHEMBL17888204 | 0.71 | NAMPT (0.44) | LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018078360-A1 | MODULATORS OF HEDGEHOG (HH) SIGNALLING PATHWAY | E-THERAPEUTICS PLC (GB) | 2018-05-03 | — | — | WO | disclosed |