Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 3/20 | 0.47 |
| ▸ | GLS | O94925 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3757316 | 0.79 | GLS (0.49) | CASP3GLSCA1CA2CA4 | |
| SCHEMBL6029821 | 0.78 | GLS (0.45) | CASP3GLSCA1CA2CA4 | |
| SCHEMBL3759156 | 0.78 | CASP3 (0.49) | CASP3GLSRAB9ASMN1; SMN2NPC1 | |
| Taltrimide SCHEMBL29866257 | 0.75 | NPSR1 (0.48) | CASP3GLSCA1CA2CA4 | |
| Taltrimide SCHEMBL347001 | 0.75 | NPSR1 (0.48) | CASP3GLSCA1CA2CA4 | |
| SCHEMBL11014716 | 0.74 | KDM4E (0.49) | GLSCA9POLBMEN1KMT2A | |
| SCHEMBL496740 | 0.73 | GLS (0.53) | CASP3GLSRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL12128890 | 0.73 | GLS (0.53) | CASP3GLSRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL29015041 | 0.73 | GLS (0.53) | CASP3GLSRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL1306411 | 0.73 | GLS (0.53) | CASP3GLSCA1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018078360-A1 | MODULATORS OF HEDGEHOG (HH) SIGNALLING PATHWAY | E-THERAPEUTICS PLC (GB) | 2018-05-03 | — | — | WO | disclosed |