Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM7 | Q14831 | 1/20 | 0.59 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.42 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.39 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 4/20 | 0.37 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20113080 | 0.82 | GRM7 (0.74) | GRM7SCN9ASCN5AKCNH2MAPT | |
| SCHEMBL20113019 | 0.80 | GRM7 (0.68) | GRM7SCN9ASCN5AKCNH2 | |
| SCHEMBL20113106 | 0.80 | GRM7 (0.74) | GRM7PRMT5WDR77SCN9ASCN5A | |
| SCHEMBL20113020 | 0.80 | GRM7 (0.68) | GRM7SCN9ASCN5A | |
| SCHEMBL20113104 | 0.80 | GRM7 (0.74) | GRM7PRMT5WDR77SCN9ASCN5A | |
| SCHEMBL20113103 | 0.80 | GRM7 (0.65) | GRM7 | |
| SCHEMBL20112967 | 0.77 | GRM7 (0.58) | GRM7SCN9ASCN5AKCNH2 | |
| SCHEMBL20113084 | 0.75 | GRM7 (0.66) | GRM7PRMT5WDR77SCN9ASCN5A | |
| SCHEMBL20113021 | 0.75 | GRM7 (0.78) | GRM7 | |
| SCHEMBL20112955 | 0.75 | GRM7 (1.00) | GRM7MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018079862-A1 | MGLUR7 MODULATORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-05-03 | — | — | WO | disclosed |