Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 16/20 | 0.64 |
| ▸ | SCN5A | Q14524 | 13/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.64 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.51 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.51 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.51 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.49 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20113177 | 0.90 | GRM7 (0.52) | SCN9ASCN5AKCNH2KCNQ2KCNA5 | |
| SCHEMBL13568403 | 0.78 | SCN9A (1.00) | SCN9ASCN5AKCNH2KCNQ2KCNA5 | |
| SCHEMBL19953612 | 0.78 | L3MBTL1 (0.46) | GRM7 | |
| SCHEMBL19953623 | 0.78 | L3MBTL1 (0.46) | GRM7 | |
| SCHEMBL19960682 | 0.78 | GRM7 (0.43) | SCN9ASCN5AKCNH2GRM7 | |
| SCHEMBL19960807 | 0.75 | LMNA (0.41) | SCN9ASCN5AKCNH2P2RX7GRM7 | |
| SCHEMBL3891943 | 0.73 | SCN9A (0.80) | SCN9ASCN5AKCNH2KCNQ2KCNA5 | |
| SCHEMBL20113104 | 0.72 | GRM7 (0.74) | SCN9ASCN5AKCNH2GRM7 | |
| SCHEMBL20113106 | 0.72 | GRM7 (0.74) | SCN9ASCN5AKCNH2GRM7 | |
| SCHEMBL20113178 | 0.71 | GRM7 (0.54) | SCN9ASCN5AKCNH2GRM7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018079862-A1 | MGLUR7 MODULATORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-05-03 | — | — | WO | disclosed |