Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.35 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL570312 | 0.89 | TSHR (0.44) | TSHRALOX5PTGS2SMN1; SMN2TUBB1 | |
| SCHEMBL396273 | 0.85 | MAPT (0.37) | ESR1ESR2MAPTNPSR1LMNA | |
| SCHEMBL19709406 | 0.81 | MAPT (0.45) | TSHRALOX5PTGS2SMN1; SMN2TUBB1 | |
| SCHEMBL27028586 | 0.80 | ALOX5 (0.44) | ALOX5PTGS2ESR1ESR2 | |
| SCHEMBL983915 | 0.80 | ALOX5 (0.44) | ALOX5PTGS2ESR1ESR2TUBB1 | |
| SCHEMBL5852205 | 0.77 | ALOX5 (0.45) | TSHRALOX5PTGS2SMN1; SMN2TUBB1 | |
| SCHEMBL1129074 | 0.77 | MAPT (0.45) | TSHRALOX5PTGS2SMN1; SMN2TUBB1 | |
| SCHEMBL24436801 | 0.77 | MAPK1 (0.42) | TSHRPTGS2TUBB1MAPTLMNA | |
| SCHEMBL24445889 | 0.77 | HMGCR (0.45) | TSHRPTGS2ESR1ESR2TUBB1 | |
| SCHEMBL19691580 | 0.77 | CA3 (0.36) | ESR1ESR2MAPTNPSR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2328903-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETASECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2011-06-08 | — | — | EP | disclosed |
| WO-2010030954-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETASECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2010-03-18 | — | — | WO | disclosed |