Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | HMGCR | P04035 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL983129 | 0.92 | PTGS2 (0.44) | ALOX5PTGS2HMGCRPTPN1DPP4 | |
| SCHEMBL27028586 | 0.83 | ALOX5 (0.44) | ALOX5PTGS2HMGCRESR1ESR2 | |
| SCHEMBL13993593 | 0.82 | LCK (0.52) | ALOX5PTGS2HMGCRPTPN1DPP4 | |
| SCHEMBL29560669 | 0.82 | LCK (0.52) | ALOX5PTGS2HMGCRPTPN1DPP4 | |
| SCHEMBL7788363 | 0.80 | ALOX5 (0.48) | ALOX5PTGS2PTPN1DPP4HTT | |
| SCHEMBL8579736 | 0.80 | ALOX5 (0.48) | ALOX5PTGS2PTPN1DPP4CYP1A1 | |
| SCHEMBL24445889 | 0.80 | HMGCR (0.45) | PTGS2HMGCRESR1ESR2HTT | |
| SCHEMBL435716 | 0.80 | POLB (0.41) | ALOX5PTGS2HTTLMNAMAPK1 | |
| SCHEMBL30745361 | 0.80 | POLB (0.41) | ALOX5PTGS2HTTLMNAMAPK1 | |
| SCHEMBL984259 | 0.80 | KDM4E (0.33) | HMGCRPTPN1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210337789-A1 | Derivatives of m-Guaiacol, Their Preparation and Their Uses | UNIVERSITE DE CAEN NORMANDIE (FR) | 2021-11-04 | — | — | US | disclosed |
| EP-3817551-A1 | M-GUAIACOL DERIVATIVES, PREPARATION THEREOF, AND USES THEREOF | Université de Caen Normandie (FR) | 2021-05-12 | — | — | EP | disclosed |
| WO-2020007882-A1 | M-GUAIACOL DERIVATIVES, PREPARATION THEREOF, AND USES THEREOF | UNIVERSITE DE CAEN NORMANDIE (FR) | 2020-01-09 | — | — | WO | disclosed |
| WO-2020007882-A1 | M-GUAIACOL DERIVATIVES, PREPARATION THEREOF, AND USES THEREOF | UNIVERSITE DE CAEN NORMANDIE (FR) | 2020-01-09 | — | — | WO | disclosed |
| US-9376442-B2 | Methylpyrrolopyrimidinecarboxamides | TAKEDA GMBH (DE) | 2016-06-28 | — | — | US | disclosed |
| US-20150073001-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | ASTRAZENECA AB (SE) | 2015-03-12 | — | — | US | disclosed |
| US-8927557-B2 | Methylpyrrolopyrimidinecarboxamides | TAKEDA GMBH (DE) | 2015-01-06 | — | — | US | disclosed |
| EP-2470536-B1 | Methylpyrrolopyrimidinecarboxamides | TAKEDA GMBH (DE) | 2014-11-12 | — | — | EP | disclosed |
| US-8816085-B2 | Methylpyrrolopyridinecarboxamides | TAKEDA GMBH (DE) | 2014-08-26 | — | — | US | disclosed |
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | disclosed |
| EP-2470536-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | Nycomed GmbH (DE) | 2012-07-04 | — | — | EP | disclosed |
| EP-2470531-A1 | METHYLPYRROLOPYRIDINECARBOXAMIDES | Nycomed GmbH (DE) | 2012-07-04 | — | — | EP | disclosed |
| US-20120149721-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2012-06-14 | — | — | US | disclosed |
| US-20120142633-A1 | METHYLPYRROLOPYRIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2012-06-07 | — | — | US | disclosed |
| WO-2011023696-A1 | METHYLPYRROLOPYRIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2011-03-03 | — | — | WO | disclosed |
| WO-2011023693-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2011-03-03 | — | — | WO | disclosed |
| US-20110021479-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2011-01-27 | — | — | US | disclosed |
| EP-2247594-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | Nycomed GmbH (DE) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009106531-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2009-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021479-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | PDE5A, PDE3A, PDE2A | ALOX5 349/4885PTGS2 221/4885HMGCR 3030/4885 |
| US-20210337789-A1 | Derivatives of m-Guaiacol, Their Preparation and Their Uses | MPG, MGLL, GANC | ALOX5 829/4885PTGS2 2391/4885HMGCR 852/4885 |
| US-20120142633-A1 | METHYLPYRROLOPYRIDINECARBOXAMIDES | PDE5A, PDE3A, PDE2A | ALOX5 1411/4885PTGS2 439/4885HMGCR 2800/4885 |
| US-20120149721-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | PDE5A, PDE12, PDE4A | ALOX5 1150/4885PTGS2 360/4885HMGCR 2382/4885 |
| US-20150073001-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | PDE12, PDE5A, PDE4A | ALOX5 867/4885PTGS2 177/4885HMGCR 1850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.