SCHEMBL20115833

SCHEMBL20115833

N#Cc1cccc2c1[nH]c1c(C#N)cccc12

nearest known ligand 0.47

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
DYRK1A Q13627 6/20 0.47
CA1 P00915 1/20 0.45
CA2 P00918 1/20 0.45
IMPDH2 P12268 2/20 0.42
IMPDH1 P20839 2/20 0.42
CLK1 P49759 1/20 0.41
PTGES O14684 1/20 0.40
JAK2 O60674 1/20 0.40
TBXAS1 P24557 1/20 0.40
GSK3B P49841 2/20 0.40
NFATC1 O95644 1/20 0.40
PNMT P11086 1/20 0.40
AR P10275 1/20 0.40
TSHR P16473 1/20 0.39
MCL1 Q07820 1/20 0.39
HTT P42858 1/20 0.38
SLC6A4 P31645 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29732438 1.00 DYRK1A (0.47) DYRK1ACA1CA2IMPDH2IMPDH1
SCHEMBL31628356 0.88 FEN1 (0.40) DYRK1ACA1CA2IMPDH2IMPDH1
SCHEMBL9714208 0.86 DYRK1A (0.54) DYRK1ACA1CA2IMPDH2IMPDH1
SCHEMBL6696776 0.86 DYRK1A (0.41) DYRK1ACA1CA2IMPDH2IMPDH1
SCHEMBL30355317 0.86 DYRK1A (0.54) DYRK1ACA1CA2IMPDH2IMPDH1
SCHEMBL11738020 0.81 DYRK1A (0.44) DYRK1ACA1CA2PTGESJAK2
SCHEMBL28848130 0.80 AHR (0.58) DYRK1ACA1CA2IMPDH2IMPDH1
SCHEMBL20115856 0.80 DYRK1A (0.49) DYRK1ACA1CA2IMPDH2IMPDH1
SCHEMBL28051627 0.78 AR (0.70) DYRK1AIMPDH2IMPDH1CLK1GSK3B
SCHEMBL20865130 0.77 PRKCA (0.60) GSK3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023277645-A1 ORGANIC MOLECULES FOR OPTOELECTRONIC DEVICES SAMSUNG DISPLAY CO., LTD. (KR) 2023-01-05 WO disclosed
CN-111875534-B Safe and efficient preparation method of 1, 8-diformylcarbazole 烟台大学 2022-06-17 CN disclosed
CN-111875534-A Safe and efficient preparation method of 1, 8-diformylcarbazole 烟台大学 2020-11-03 CN disclosed
US-20200308196-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES THE UNIVERSITY OF SOUTHERN CALIFORNIA 2020-10-01 US disclosed
EP-3119770-B1 NEW DIBENZOFURANS AND DIBENZOTHIOPHENES IDEMITSU KOSAN CO (JP) 2018-05-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200308196-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES L1CAM, SOD1, EML4 DYRK1A 4453/4885CA1 1707/4885CA2 2009/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.