Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.33 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6236000 | 0.79 | HRH1 (0.48) | HRH1SLC6A4SLC6A2SLC6A3ALDH1A1 | |
| SCHEMBL2011752 | 0.77 | NPC1 (0.42) | MAPTMEN1KMT2AHPGDHTT | |
| SCHEMBL8777076 | 0.74 | HRH1 (0.50) | HRH1SLC6A4SLC6A2SLC6A3TDP1 | |
| SCHEMBL10873734 | 0.73 | SLC6A4 (0.66) | SLC6A4SLC6A2SLC6A3ALDH1A1L3MBTL1 | |
| SCHEMBL11100370 | 0.73 | HRH1 (0.44) | HRH1SLC6A4SLC6A2SLC6A3KDM4E | |
| SCHEMBL6264119 | 0.73 | KDM4E (0.42) | SLC6A4SLC6A2SLC6A3MAPTPOLB | |
| Bromide SCHEMBL7930547 | 0.72 | KDM4E (0.41) | SLC6A4SLC6A2SLC6A3MAPTPOLB | |
| SCHEMBL10873183 | 0.71 | MEN1 (0.49) | SLC6A4SLC6A2SLC6A3MAPTSMN1; SMN2 | |
| SCHEMBL7405866 | 0.71 | SLC6A4 (0.50) | HRH1SLC6A4MAOAMAPTPOLB | |
| SCHEMBL2011606 | 0.71 | P2RX3 (0.37) | SLC6A4SLC6A2SLC6A3MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073273-A1 | BENZOXAZINE ARYL SULFONAMIDE DERIVATIVES AS KV1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011073276-A1 | BENZOXAZINE ARYL SULFONAMIDE DERIVATIVES AS KV1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | disclosed |