Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4440523 | 0.79 | P2RX3 (0.42) | P2RX3P2RX2ALDH1A1LMNAKMT2A | |
| SCHEMBL2011750 | 0.77 | L3MBTL1 (0.43) | MAPTPOLBALDH1A1MEN1LMNA | |
| SCHEMBL10873729 | 0.75 | SLC6A4 (0.52) | P2RX3P2RX2ALDH1A1L3MBTL1SLC6A2 | |
| SCHEMBL6264176 | 0.74 | PTPRC (0.40) | MAPTPOLBALDH1A1MEN1HTT | |
| SCHEMBL3984863 | 0.73 | KDM4E (0.42) | MAPTPOLBALDH1A1MEN1HTT | |
| SCHEMBL10873178 | 0.72 | ADRA2A (0.52) | P2RX3P2RX2MAPTALDH1A1MEN1 | |
| SCHEMBL10872553 | 0.71 | P2RX3 (0.39) | P2RX3P2RX2MEN1KMT2AATM | |
| SCHEMBL10874957 | 0.71 | ALDH1A1 (0.40) | P2RX3P2RX2LPAR1ALDH1A1MEN1 | |
| SCHEMBL7405866 | 0.71 | SLC6A4 (0.50) | MAPTPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL16564328 | 0.71 | LPAR1 (0.43) | LPAR1LMNATDP1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073273-A1 | BENZOXAZINE ARYL SULFONAMIDE DERIVATIVES AS KV1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011073276-A1 | BENZOXAZINE ARYL SULFONAMIDE DERIVATIVES AS KV1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | disclosed |