Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2013300 | 0.82 | HPGD (0.40) | NPC1RAB9AGBA1MAPK1L3MBTL1 | |
| SCHEMBL4343294 | 0.77 | TSHR (0.41) | RAB9AMAPK1L3MBTL1CCR5MAPT | |
| SCHEMBL2011608 | 0.77 | HRH1 (0.37) | MAPK1L3MBTL1HPGDMAPTALDH1A1 | |
| SCHEMBL1241970 | 0.76 | S100A4 (0.44) | RAB9AMAPK1ACHEALDH1A1TSHR | |
| SCHEMBL2013294 | 0.75 | KMT2A (0.55) | NPC1RAB9AGBA1MAPK1L3MBTL1 | |
| SCHEMBL17506413 | 0.75 | HTR6 (0.54) | NPC1RAB9AGBA1MAPK1L3MBTL1 | |
| SCHEMBL30026729 | 0.75 | HTR6 (0.54) | NPC1RAB9AGBA1MAPK1L3MBTL1 | |
| SCHEMBL2011750 | 0.74 | L3MBTL1 (0.43) | NPC1RAB9AGBA1MAPK1L3MBTL1 | |
| SCHEMBL6236000 | 0.73 | HRH1 (0.48) | ALDH1A1TDP1 | |
| SCHEMBL29182853 | 0.72 | NPC1 (0.46) | NPC1RAB9AGBA1MAPK1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073276-A1 | BENZOXAZINE ARYL SULFONAMIDE DERIVATIVES AS KV1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011073273-A1 | BENZOXAZINE ARYL SULFONAMIDE DERIVATIVES AS KV1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | disclosed |