Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 4/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26436619 | 0.84 | ALDH1A1 (0.34) | CHEK1PARP1PIM1RPS6KA3NQO2 | |
| SCHEMBL22358065 | 0.82 | LMNA (0.36) | MPOALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL16596064 | 0.82 | RET (0.36) | MPOSMN1; SMN2HRH4LMNARET | |
| SCHEMBL17616025 | 0.77 | MPO (0.61) | MPOCYP1A2ALDH1A1SMN1; SMN2CASP1 | |
| SCHEMBL12163 | 0.75 | KIT (0.41) | CHEK1PARP1PIM1RPS6KA3NQO2 | |
| SCHEMBL20116565 | 0.70 | GRM4 (0.44) | SMN1; SMN2NR1I2EGFRADRA2AADORA3 | |
| SCHEMBL20116566 | 0.70 | KDM4E (0.40) | CHEK1PARP1PIM1RPS6KA3CYP1A2 | |
| SCHEMBL27051630 | 0.68 | RET (0.38) | ALDH1A1SMN1; SMN2NR1I2EGFRADRA2A | |
| SCHEMBL27051631 | 0.68 | NR1I2 (0.38) | ALDH1A1SMN1; SMN2NR1I2EGFRADRA2A | |
| SCHEMBL26373750 | 0.68 | NR1I2 (0.38) | NR1I2EGFRADRA2AADORA3TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019209948-A9 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-01-02 | — | — | WO | disclosed |
| WO-2019018795-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2019-01-24 | — | — | WO | disclosed |
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |