Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21120831 | 0.85 | MCHR1 (0.42) | KDM4EALDH1A1SMN1; SMN2HPGDLMNA | |
| SCHEMBL22357765 | 0.80 | ADORA2A (0.35) | KDM4EALDH1A1SMN1; SMN2HPGDCYP1A2 | |
| SCHEMBL12163 | 0.75 | KIT (0.41) | KDM4EALDH1A1CYP1A2LMNAMAPT | |
| SCHEMBL16369689 | 0.71 | LMNA (0.42) | KDM4EALDH1A1SMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL15792334 | 0.71 | ADORA2A (0.37) | KDM4EALDH1A1SMN1; SMN2HPGDLMNA | |
| SCHEMBL20116573 | 0.70 | ADORA2A (0.67) | SMN1; SMN2LMNAHTTADORA2AADORA2B | |
| SCHEMBL20116571 | 0.70 | MPO (0.38) | KDM4EALDH1A1SMN1; SMN2CYP1A2LMNA | |
| SCHEMBL15617395 | 0.70 | GPR139 (0.56) | ALDH1A1SMN1; SMN2LMNAHTTKMT2A | |
| SCHEMBL28710100 | 0.68 | APOBEC3A (0.36) | KDM4EALDH1A1SMN1; SMN2HPGDCYP1A2 | |
| SCHEMBL3483114 | 0.68 | ADORA2A (0.33) | KDM4ESMN1; SMN2LMNAHTTADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019209948-A9 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-01-02 | — | — | WO | disclosed |
| WO-2019018795-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2019-01-24 | — | — | WO | disclosed |
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |