Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ACSS2 | Q9NR19 | 4/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | CCNC | P24863 | 2/20 | 0.39 |
| ▸ | CDK8 | P49336 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30147538 | 0.89 | PLK1 (0.49) | PLK1THRBPLAUTDP1SMN1; SMN2 | |
| SCHEMBL29241319 | 0.71 | HCAR3 (0.49) | TDP1SMN1; SMN2 | |
| SCHEMBL30147606 | 0.69 | PTGER3 (0.46) | PLK1PLAUACSS2HDAC4CCNC | |
| SCHEMBL15910725 | 0.69 | KDM4E (0.56) | PLAUSMN1; SMN2HDAC4SYK | |
| SCHEMBL30147618 | 0.69 | ALDH1A1 (0.46) | PLK1THRBSMN1; SMN2HPGDSCYP3A4 | |
| SCHEMBL26425463 | 0.67 | GAA (0.43) | SMN1; SMN2 | |
| SCHEMBL25398530 | 0.66 | SMN1; SMN2 (0.41) | TDP1SMN1; SMN2 | |
| SCHEMBL9989122 | 0.66 | PLK1 (0.48) | PLK1THRBPLAUTDP1SMN1; SMN2 | |
| SCHEMBL2299005 | 0.66 | PLK1 (0.77) | PLK1TDP1HDAC6 | |
| SCHEMBL17741451 | 0.66 | BACE1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115551864-A | Substituted tricyclic amides, analogs thereof, and methods of using the same | 爱彼特生物制药公司 | 2022-12-30 | — | — | CN | disclosed |