Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | SMO | Q99835 | 6/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20117187 | 0.87 | MAPT (0.44) | MAPTLMNANPC1HTTTP53 | |
| SCHEMBL20676645 | 0.85 | KIT (0.40) | MAPTLMNATP53SMOPOLB | |
| SCHEMBL20116725 | 0.81 | MAPT (0.39) | MAPTLMNANPC1HTTFAAH | |
| SCHEMBL20116872 | 0.81 | MAPT (0.40) | MAPTLMNANPC1HTTTP53 | |
| SCHEMBL20116816 | 0.79 | TBK1 (0.39) | HTTSMO | |
| SCHEMBL20116844 | 0.76 | MAPT (0.35) | MAPTLMNANPC1HTT | |
| SCHEMBL20116803 | 0.76 | MAPT (0.38) | MAPTLMNANPC1HTTTP53 | |
| SCHEMBL20116712 | 0.76 | MAPT (0.41) | MAPTLMNANPC1HTTTP53 | |
| SCHEMBL20676430 | 0.75 | LMNA (0.41) | LMNAHTTSMOGAA | |
| SCHEMBL20676648 | 0.74 | MAPT (0.40) | MAPTLMNANPC1HTTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |